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    Modified Atkins Diet Can Cut Epileptic Seizures In Adults
    ScienceDaily (Jan. 28, 2008) — A modified version of a popular high-protein, low-carbohydrate diet can significantly cut the number of seizures in adults with epilepsy, a study led by Johns Hopkins researchers suggests. The Atkins-like diet, which has shown promise for seizure control in children, may offer a new lifeline for patients when drugs and other treatments fail or cause complications.—For almost a century, doctors have prescribed an eating plan called the ketogenic diet to treat children with epilepsy. This diet often consists of a short period of fasting, strictly limits fluids and drastically restricts carbohydrates. It appears to limit or even eliminate seizures, possibly by generating the build-up of ketones, compounds the body produces when it derives calories mostly from fat. Some of the largest studies to scientifically test this diet’s efficacy took place at Johns Hopkins in the mid-1990s, led by pediatric neurologists John Freeman, M.D., and Eileen Vining, M.D.—Why exactly the ketogenic diet works remains unknown, and it is notoriously difficult to follow, relying almost solely on fat and protein for calories. Consequently, doctors typically recommend it only for children, whose parents can strictly monitor their eating habits. The ketogenic diet is almost never prescribed to adults, who generally make their own food choices and often have difficulty complying with the diet’s strict guidelines.—In 2002, Johns Hopkins researchers began testing a modified version of the Atkins diet in children with epilepsy. The modified diet shares the high-fat focus of the ketogenic diet, prompting the body to generate ketones. However, it allows more carbohydrates and protein, doesn’t limit fluids and calories, and has no fasting period. When studies showed that the new diet prevented or curtailed seizures in children, the researchers began testing it for efficacy and ease of use in adults.—Reporting on the results in the February issue of Epilepsia, Eric H. Kossoff, M.D., an assistant professor of neurology and pediatrics at the Johns Hopkins University School of Medicine, said 30 adults with epilepsy, ages 18 to 53 years, who had tried at least two anticonvulsant drugs without success and had an average of 10 seizures per week, were placed on the modified Atkins diet. All patients were seen for free in the Johns Hopkins General Clinical Research Center.—-The regimen restricted them to 15 grams of carbohydrates a day. “That’s a few strawberries, some vegetables, or a bit of bread,” says Kossoff. The diet offers most of its calories from fat-eggs, meats, oils and heavy cream-with as much protein and no-carb beverages as patients want.—Each day, patients kept diaries of what they ate and how many seizures they had. The researchers evaluated how each patient was doing at one, three and six months after starting the diet.—-Results showed that about half the patients had experienced a 50 percent reduction in the frequency of their seizures by the first clinic visit. About a third of the patients halved the frequency of seizures by three months. Side effects linked with the diet, such as a rise in cholesterol or triglycerides, were mild. A third of the patients dropped out by the third month, unable to comply with the restrictions.—Fourteen patients who stuck with the diet until the six-month mark chose to continue, even after the study ended-a testament to how effective the diet worked to treat their epilepsy, Kossoff notes.—Though the modified Atkins diet won’t be a good fit for all patients, says Kossoff, “it opens up another therapeutic option for adults trying to decide between medication, surgery and electrical stimulation to treat intractable seizures.” A second study to examine the diet’s effects on adults with intractable seizures is under way.—Other researchers who contributed to the study include Hannah Rowley, R.D., and Eileen P.G. Vining, M.D., both of the Johns Hopkins University School of Medicine, and Saurabh R. Sinha, M.D., of Sinai Hospital of Baltimore.—Story Source:–Adapted from materials provided by Johns Hopkins Medical Institutions.
    Diet May Eliminate Spasms For Infants With Epilepsy
    ScienceDaily (Sep. 10, 2008) — Infantile spasms are a severe and potentially devastating epilepsy condition affecting children aged typically 4-8 months. In a new study appearing in Epilepsia, researchers have found that the ketogenic diet, a high fat, low carbohydrate diet more traditionally used for intractable childhood epilepsy, is an effective treatment for this condition before using drugs.—The study is the first description of the ketogenic diet as a first-line therapy for infantile spasms.—ACTH and vigabatrin, medications that are the commonly-used first treatments worldwide, can have potentially-serious side effects such as hypertension, gastric ulceration, cortical atrophy, and visual field constriction. ACTH, though it is effective in 60-70 percent of cases, also costs more than $80,000 for a one-month supply and vigabatrin is not currently available in the U.S. Both drugs have about a 30-40 percent recurrence rate of spasms as well. Other therapies are not yet proven.—“We decided to review our experience at Johns Hopkins using the ketogenic diet to treat infantile spasms before medications were tried and compare this to our use of ACTH over the same time period,” says Eric Kossoff, M.D, a pediatric neurologist at Johns Hopkins Hospital and lead author of the study. “We knew that the ketogenic diet worked well for difficult-to-control infantile spasms, so we thought it would also be effective earlier.”—-If the diet stopped the spasms, infants were kept on it for usually 6 months. The diet worked in 8-of-13 infants within approximately one week. Only 1-of-8 had recurring spasms, and that infant was controlled again with the addition of topiramate to the diet. Side effects were fewer than ACTH in this series and the recurrence rate was also lower with the diet. In the 5 patients in which the diet did not work, ACTH was started immediately; it worked quickly in 4 of the 5 infants. ACTH did lead to a normal EEG quicker, but long-term developmental outcomes were identical.—As a result of the findings, the ketogenic diet is now one of the typically-offered first-line therapies for new-onset infantile spasms at Johns Hopkins. Other hospitals are beginning to use the ketogenic diet similarly. The researchers hope this novel use of the ketogenic diet may be the first step in finding another treatment to control new-onset infantile spasms.—Story Source:–Adapted from materials provided by Wiley-Blackwell, via EurekAlert!, a service of AAAS
    Daily Potassium Citrate Wards Off Kidney Stones In Seizure Patients On High-Fat Diet
    ScienceDaily (July 27, 2009) — Children on the high-fat ketogenic diet to control epileptic seizures can prevent the excruciatingly painful kidney stones that the diet can sometimes cause if they take a daily supplement of potassium citrate the day they start the diet, according to research from Johns Hopkins Children’s Center.—“We can confidently say this is a safe and powerful way to prevent kidney stones, and it should become part of standard therapy in all ketogenic dieters, not just those who already show elevated urine calcium levels,” says senior investigator Eric Kossoff, M.D., a pediatric neurologist at Hopkins Children’s. “If you wait, it might be too late.”—The ketogenic diet, believed to work by initiating biochemical changes that eliminate seizure-triggering short circuits in the brain’s signaling system, is given to many children whose seizures do not respond to medications. But the diet, which consists of high-fat foods with very few carbohydrates, causes a buildup of calcium in the urine and the formation of kidney stones in about 6 percent of those on it.—Hopkins Children’s adopted the preventive treatment with potassium citrate two years ago, and doctors now believe this one major side effect of the diet is a thing of the past, allowing more children to remain on the diet for longer.—Potassium citrate taken twice daily, either as powder sprinkled on food or dissolved in water, is believed to inhibit stone formation.—In their study of 301 children treated for epilepsy with the ketogenic diet at Hopkins Children’s the researchers found that those who got potassium citrate twice daily were seven times less likely to develop kidney stones — one of 106 (0.9 percent) developed a kidney stone compared to 13 out of 195 (6.7 percent) who were given potassium citrate only after testing positive for elevated levels of blood calcium. Most children received one 30-milliequivalent packet (about 1, 170 milligrams or 0.04 ounces) of potassium citrate twice daily.—Although rarely serious, kidney stones can cause significant pain, along with kidney and urinary tract infections, and may require surgery.—The research was funded in part by the NIH and the Carson Harris Foundation.–A report on the work is published in the August issue of Pediatrics. Co-investigators include: Melanie McNally, B.S.; Paula Pyzik, B.S.; James Rubenstein, M.D.; Rana Hamdy, M.D. M.P.H.–Story Source: Adapted from materials provided by Johns Hopkins Medical Institutions, via EurekAlert!, a service of AAAS
    High-Fat Ketogenic Diet Effectively Treats Persistent Childhood Seizures, Study Finds
    ScienceDaily (May 18, 2010) — The high-fat ketogenic diet can dramatically reduce or completely eliminate debilitating seizures in most children with infantile spasms, whose seizures persist despite medication, according to a Johns Hopkins Children’s Center study published online April 30 in the journal Epilepsia.—Infantile spasms, also called West syndrome, is a stubborn form of epilepsy that often does not get better with antiseizure drugs. Because poorly controlled infantile spasms may cause brain damage, the Hopkins team’s findings suggest the diet should be started at the earliest sign that medications aren’t working.–“Stopping or reducing the number of seizures can go a long way toward preserving neurological function, and the ketogenic diet should be our immediate next line of defense in children with persistent infantile spasms who don’t improve with medication,” says senior investigator Eric Kossoff, M.D., a pediatric neurologist and director of the ketogenic diet program at Hopkins Children’s.—The ketogenic diet, made up of high-fat foods and few carbohydrates, works by triggering biochemical changes that eliminate seizure-causing short circuits in the brain’s signaling system. It has been used successfully in several forms of epilepsy.—A small 2002 study by the same Hopkins team showed the diet worked well in a handful of children with infantile spasms. The new study is the largest analysis thus far showing just how effective the diet can be in children with this condition.—Of the 104 children treated by the Hopkins team, nearly 40 percent, or 38 children, became seizure-free for at least six months after being on the diet for anywhere from just a few days to 20 months. Of the 38, 30 have remained so without a relapse for at least two years.—After three months on the diet, one-third of the children had 90 percent fewer seizures, and after nine months on the diet, nearly half of the children in the study had 90 percent fewer seizures. Nearly two-thirds had half as many seizures after six months on the diet.—Nearly two-thirds of the children experienced improvement in their neurological and cognitive development, and nearly 30 percent were weaned off antiseizure medications after starting the diet.—Most of the children continued taking their medication even after starting the diet, the researchers say, because the two are not mutually exclusive and can often work in synergy.—Researchers also used the diet as first-line therapy in18 newly diagnosed infants never treated with drugs, 10 of whom became seizure free within two weeks of starting the diet. The finding suggests that, at least in some children, the diet may work well as first-line therapy, but the researchers say they need further and larger studies to help them identify patients for whom the diet is best used before medications. Hopkins Children’s neurologists are actively using the ketogenic diet as first-line treatment in children with infantile spasms with promising results.—Side effects, including constipation, heartburn, diarrhea and temporary spikes in cholesterol levels, occurred in one-third of the children, with six percent of them experiencing diminished growth.—Despite these side effects, a recent study by Kossoff and his team showed that the ketogenic diet is safe long term.—Conflict of interest disclosure: Dr. Kossoff has received grant support from Nutricia Inc., for unrelated research. The terms of these arrangements are being managed by the Johns Hopkins University in accordance with its conflict-of-interest policies.—-The research was funded in part by the National Institutes of Health.—Co-investigators include Amanda Hong, Zahava Turner and Rana Hamdy, all of Hopkins.—Story Source: Adapted from materials provided by Johns Hopkins Medical Institutions, via EurekAlert!, a service of AAAS.—Journal Reference: Amanda M. Hong, Zahava Turner, Rana F. Hamdy, Eric H. Kossoff. Infantile spasms treated with the ketogenic diet: Prospective single-center experience in 104 consecutive infants. Epilepsia, 2010; DOI: 10.1111/j.1528-1167.2010.02586.x
    Recipe Combo For Taurine/Potassium/ Magnesium—
    Take 1 gram of Taurine with 1 gram of potassium and magnesium so this can be incorporated more readily into the cells and into the heart where it can regulate blood flow and pressure the Taurine as well regulates bile out of the liver allowing for better utilization of the fats and to not allow gall stones
    Recipe Combo for a Ketogenic Smoothie
    Take Coconut Milk poor into a blender add 1 ounce of peanut oil
    Add avocado ( whole and peeled) add whey protein powder ( 25 grams or 2 tablespoons) sweeten with either vanilla or honey or maple syrup–Add xanthium gum ( 1 tablespoon ) add water add coconut cream 1 tablespoon
    Blend till fused —chill and consume
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    Show of the Week May 28 2010
    Work exposure to soy tied to asthma symptoms
    Pesticide Exposure May Contribute to ADHD, Study Finds
    Pesticides on Produce Tied to ADHD in Children—Organophosphates may alter chemistry of developing brain, researchers say
    Study suggests processed meat a real health risk
    Recipe On C + NAC—And Garlic +Green Tea +Vitamin C + Bioflavonoid
    Work exposure to soy tied to asthma symptoms–
    NEW YORK (Reuters Health) – Allergic reactions to soy may be a cause of asthma symptoms in some workers at soy processing plants, a new —study suggests.—Soy is among the most common sources of food allergies, and some studies have found that people who work in soy processing have higher-than-average rates of respiratory symptoms such as wheezing.—Those findings raised the question of whether breathing in soy “dust” may lead to airway inflammation and asthma in some workers.—-For the new study, researchers at the U.S. Centers for Disease Control and Prevention (CDC) assessed employees at a Tennessee soy processing plant, at the request of workers who believed that their respiratory symptoms were related to workplace exposures.—They found that the 281 workers they interviewed had higher-than-average rates of wheezing and current, doctor-diagnosed asthma. Nine percent had asthma — 70 percent higher than the rate among U.S. adults, based on a national health survey from the early 1990s. In addition, 29 percent had suffered bouts of wheezing in the past year, double the prevalence among U.S. adults.—-Blood tests further showed that the workers were more likely to have immune system antibodies against soy, when compared against 50 healthcare workers used for a “control” group.—Twenty-one percent had IgE antibodies against soy, versus 4 percent of the control group; IgE antibodies are involved in triggering allergic reactions. Employees with IgE antibodies against soy were three times more likely than their co-workers to have asthma or asthma-like symptoms.—The findings are the first to show an association between soy allergy and asthma symptoms among soy workers, according to lead researcher Dr. Kristin J. Cummings, of the CDC’s National Institute for Occupational Safety and Health.—-They suggest that such allergies are responsible for at least some workers’ asthma, she said in an interview.—The plant her team studied was responsible for taking crushed soy “flakes” and further processing them into soy powder products. Cummings said she and her colleagues believe that airborne soy dust was responsible for some workers’ allergy development and respiratory symptoms.—“We recommend reducing workers’ exposure through engineering changes, better ventilation and respiratory protection,” Cummings said.—She also suggested that soy workers who think they have respiratory problems related to their job discuss it with their doctors.—Cummings noted that not all workers with asthma and asthma-like symptoms had antibodies to soy. But that, she said, does not mean that their problems are unrelated to their jobs. Other workplace exposures — to mold, for example, or high levels of dust in general — may contribute to asthma in some people.—SOURCE: Respiratory Journal, online April 22, 2010.
    Pesticide Exposure May Contribute to ADHD, Study Finds
    ScienceDaily (May 17, 2010) — A team of scientists from the University of Montreal and Harvard University has discovered that exposure to organophosphate pesticides may be associated with increased risk of Attention-Deficit Hyperactivity Disorder (ADHD) in children.—Published in the journal Pediatrics, the investigation found a connection between exposure pesticides and the presence of symptoms of ADHD. The study focused on 1,139 children from the general U.S. population and measured pesticide levels in their urine.—The authors conclude that exposure to organophosphate pesticides, at levels common among U.S. children, may contribute to a diagnosis of ADHD.—“Previous studies have shown that exposure to some organophosphate compounds cause hyperactivity and cognitive deficits in animals,” says lead author Maryse F. Bouchard of the University of Montreal Department of Environmental and Occupational Health and the Sainte-Justine Hospital Research Center. “Our study found that exposure to organophosphates in developing children might have effects on neural systems and could contribute to ADHD behaviors, such as inattention, hyperactivity, and impulsivity.”–This study was supported by the Canadian Institutes for Health Research and the National Institute of Environmental Health Sciences.–The study was authored by Maryse F. Bouchard of the University of Montreal and Harvard University, David C. Bellinger, Robert O. Wright, and Marc G. Weisskopf of Harvard University.–Email or share this story:–Story Source:–Adapted from materials provided by University of Montreal, via EurekAlert!, a service of AAAS.–Journal Reference:–Maryse F. Bouchard, David C. Bellinger, Robert O. Wright, and Marc G. Weisskopf. Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pesticides. Pediatrics, 2010; DOI: 10.1542/peds.2009-3058
    Pesticides on Produce Tied to ADHD in Children—Organophosphates may alter chemistry of developing brain, researchers say
    MONDAY, May 17 (HealthDay News) — New research suggests that exposure to high levels of organophosphate pesticides, commonly found on berries, celery and other produce, could raise the odds for attention-deficit/hyperactivity disorder (ADHD) in children.—At this point, though, there is no evidence that pesticide exposure can actually cause ADHD, stated the authors of a paper appearing in the June issue of pediatrics. Certainly parents and children shouldn’t swear off fruits and veggies, said study lead author Maryse Bouchard, an adjunct researcher in the department of environmental and occupational health at the University of Montreal and at Sainte-Justine University Hospital Centre. However, “I think it’s safe to say that we should as much as possible reduce our exposure to pesticides,” she said.–That would meaning going organic, buying at farmers’ markets and washing fruits and vegetables thoroughly before consuming them, she said. –“I always encourage my families to embrace healthy lifestyles in general,” agreed Dr. Nakia Scott, clinical assistant professor of psychiatry and behavioral science at Texas A&M Health Science Center College of Medicine and a child psychiatrist with Lone Star Circle of Care. “I think it’s much more important that they’re eating fruits, vegetables, nuts and grains instead of sodas and fast foods and I’m not saying that they’re not going to eat any produce because it might contain pesticides.”—Previous research has shown an association between both prenatal and postnatal organophosphate exposure and developmental problems in young children. —But most prior studies have focused on excessive rather than average exposure to organophosphates. —“Organophosphates are one of the most widely used pesticides in agriculture to protect crops and fruits and vegetables,” Bouchard noted. “For children, the major source of exposure would be the diet — fruits and vegetables in particular.”—In their study, Bouchard and her colleagues analyzed data on pesticide exposure and ADHD in more than 1,100 American children aged 8 to 15. —Children with higher pesticide levels in their urine were more likely to have ADHD, the team found.—“The analysis showed that the higher the level of exposure [as measured by metabolites in the urine], the higher the odds of having ADHD,” Bouchard added. —Just how might pesticides harm brain development? According to the authors, high doses of organophosphates may inhibit acetylcholinesterase, a nervous system enzyme. Lower doses of the pesticide may affect different growth factors and neurotransmitters.–The findings, if replicated, may provide another clue into the causes of ADHD, a condition which affects three to seven percent of school-aged children, according to the U.S. Centers for Disease Control and Prevention. —“We do have a fair amount of evidence about other causes of ADHD,” Scott said. “We know that ADHD is a highly heritable disorder. At least one-third of fathers who have had ADHD in their youth have a child with ADHD.”—“There are also prenatal risks such as tobacco exposure and alcohol exposure,” she added. “There’s also a possibility that children who are exposed to high levels of lead prior to the age of six may develop ADHD.”— SOURCES: Maryse Bouchard, Ph.D., adjunct researcher, department of environmental and occupational health, University of Montreal and Sainte-Justine University Hospital Centre, Canada; Nakia Scott, M.D., clinical assistant professor, psychiatry and behavioral science, Texas A&M Health Science Center College of Medicine, and child psychiatrist, Lone Star Circle of Care, College Station, Texas; June 2010 Pediatrics
    Study suggests processed meat a real health risk
    CHICAGO (Reuters) – Eating bacon, sausage, hot dogs and other processed meats can raise the risk of heart disease and diabetes, U.S. researchers said on Monday in a study that identifies the real bad boys of the meat counter.—Eating unprocessed beef, pork or lamb appeared not to raise risks of heart attacks and diabetes, they said, suggesting that salt and chemical preservatives may be the real cause of these two health problems associated with eating meat.—The study, an analysis of other research called a meta-analysis, did not look at high blood pressure or cancer, which are also linked with high meat consumption.—“To lower risk of heart attacks and diabetes, people should consider which types of meats they are eating,” said Renata Micha of the Harvard School of Public Health, whose study appears in the journal Circulation.—“Processed meats such as bacon, salami, sausages, hot dogs and processed deli meats may be the most important to avoid,” Micha said in a statement.—Based on her findings, she said people who eat one serving per week or less of processed meats have less of a risk.—The American Meat Institute objected to the findings, saying it was only one study and that it stands in contrast to other studies and the U.S. Dietary Guidelines for Americans.—“At best, this hypothesis merits further study. It is certainly no reason for dietary changes,” James Hodges, president of the American Meat Institute, said in a statement.—Most dietary guidelines recommend eating less meat. Individual studies looking at relationships between eating meat and cardiovascular diseases and diabetes have had mixed results.—But studies rarely look for differences in risk between processed and unprocessed red meats, Micha said.—She and colleagues did a systematic review of nearly 1,600 studies from around the world looking for evidence of a link between eating processed and unprocessed red meat and the risk of heart disease and diabetes.—They defined processed meat as any meat preserved by smoking, curing or salting, or with the addition of chemical preservatives. Meats in this category included bacon, salami, sausages, hot dogs or processed deli or luncheon meats.—Unprocessed red meat included beef, lamb or pork but not poultry.They found that on average, each 1.8 oz (50 grams) daily serving of processed meat a day — one to two slices of deli meats or one hot dog — was associated with a 42 percent higher risk of heart disease and a 19 percent higher risk of developing diabetes.–They found no higher heart or diabetes risk in people who ate only unprocessed red meats.–The team adjusted for a number of factors, including how much meat people ate. They said lifestyle factors were similar between those who ate processed and unprocessed meats.
    “When we looked at average nutrients in unprocessed red and processed meats eaten in the United States, we found that they contained similar average amounts of saturated fat and cholesterol,” Micha said.—“In contrast, processed meats contained, on average, four times more sodium and 50 percent more nitrate preservatives,” Micha added.—Last month, the Institute of Medicine urged the U.S. Food and Drug Administration to regulate the amount of salt added to foods to help Americans cut their high sodium intake.—The FDA has not yet said whether it will regulate salt in foods, but it is looking at the issue.
    Recipe On C + NAC—And Garlic +Green Tea +Vitamin C + Bioflavonoid
    FTake 2000 mgs ( 2 grams of Vitamin C ) and NAC 1 gram ( 1,000 mgs of N- acetyl-Cysteine ) before drinking or smoking or in consuming meats treated with Sodium Nitrite or Sodium Nitrate –this will bind and remove the toxic elements in the consumption of these carcinogenic materials being exposed to the body
    FYou can as well Use Garlic + Vinegar + Green Tea + the Bioflavonoids of the whites of citrus fruits —You will add 6-8 cloves of garlic -1 tsp of green tea—4-5 slices of the bioflavonoid ( or about 1 oz ) and 1 cup of vinegar—put all in blender and allow to blend for a good 10 minutes at high speed bottle in glass ( strain if you like )
    These both will chelate out of you a lot of the toxic chemicals and protect the stomach and respiratory system as well as liver from harmful Carcinogens
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    Shows of the week May 31 2010
    Caffeine May Slow Alzheimer’s Disease and Other Dementias, Restore Cognitive Function
    Cup Of Coffee A Day Could Help Protect Against Alzheimer’s Disease, Study Suggests
    Coffee Drinking Protects Against An Eyelid Spasm
    Recipe for Coffee syrup
    Muscle Loss in Elderly Linked to Blood Vessels’ Failure to Dilate
    Caffeine May Slow Alzheimer’s Disease and Other Dementias, Restore Cognitive Function, According to New Evidence
    Coffee with caffeine. Caffeine may be protective against the cognitive decline seen in dementia and Alzheimer’s disease. —ScienceDaily (May 18, 2010) — Although caffeine is the most widely consumed psychoactive drug worldwide, its potential beneficial effect for maintenance of proper brain functioning has only recently begun to be adequately appreciated. Substantial evidence from epidemiological studies and fundamental research in animal models suggests that caffeine may be protective against the cognitive decline seen in dementia and Alzheimer’s disease (AD).—A special supplement to the Journal of Alzheimer’s Disease, “Therapeutic Opportunities for Caffeine in Alzheimer’s Disease and Other Neurodegenerative Diseases,” sheds new light on this topic and presents key findings.Guest editors Alexandre de Mendonça, Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Portugal, and Rodrigo A. Cunha, Center for Neuroscience and Cell Biology of Coimbra and Faculty of Medicine, University of Coimbra, Portugal, have assembled a group of international experts to explore the effects of caffeine on the brain. The resulting collection of original studies conveys multiple perspectives on topics ranging from molecular targets of caffeine, neurophysiological modifications and adaptations, to the potential mechanisms underlying the behavioral and neuroprotective actions of caffeine in distinct brain pathologies.—“Epidemiological studies first revealed an inverse association between the chronic consumption of caffeine and the incidence of Parkinson’s disease,” according to Mendonça and Cunha. “This was paralleled by animal studies of Parkinson’s disease showing that caffeine prevented motor deficits as well as neurodegeneration “Later a few epidemiological studies showed that the consumption of moderate amounts of caffeine was inversely associated with the cognitive decline associated with aging as well as the incidence of Alzheimer’s disease. Again, this was paralleled by animal studies showing that chronic caffeine administration prevented memory deterioration and neurodegeneration in animal models of aging and of Alzheimer’s disease.”–Key findings presented in “Therapeutic Opportunities for Caffeine in Alzheimer’s Disease and Other Neurodegenerative Diseases”:
    Multiple beneficial effects of caffeine to normalize brain function and prevent its degeneration
    Caffeine’s neuroprotective profile and its ability to reduce amyloid-beta production
    Caffeine as a candidate disease-modifying agent for Alzheimer’s disease
    Positive impact of caffeine on cognition and memory performance
    Identification of adenosine A2A receptors as the main target for neuroprotection afforded by caffeine consumption
    Confirmation of data through valuable meta-analyses presented
    Epidemiological studies corroborated by meta-analysis suggesting that caffeine may be protective against Parkinson’s disease
    Several methodological issues must be solved before advancing to decisive clinical trials
    Mendonça and Cunha also observe that “the daily follow-up of patients with AD has taught us that improvement of daily living may be a more significant indicator of amelioration than slight improvements in objective measures of memory performance. One of the most prevalent complications of AD is depression of mood, and the recent observations that caffeine might be a mood normalizer are of particular interest.”—The supplement was funded by the Associação Industrial e Comercial do Café, while leaving full scientific independence to all contributors. The entire issue has been made available on a no-fee basis at—Story Source:–Adapted from materials provided by IOS Press, via EurekAlert!, a service of AAAS
    Cup Of Coffee A Day Could Help Protect Against Alzheimer’s Disease, Study Suggests
    ScienceDaily (Apr. 3, 2008) — A daily dose of caffeine blocks the disruptive effects of high cholesterol that scientists have linked to Alzheimer’s disease. A study in the open access publication, Journal of Neuroinflammation revealed that caffeine equivalent to just one cup of coffee a day could protect the blood-brain barrier (BBB) from damage that occurred with a high-fat diet.—-The BBB protects the central nervous system from the rest of the body’s circulation, providing the brain with its own regulated microenvironment. Previous studies have shown that high levels of cholesterol break down the BBB which can then no longer protect the central nervous system from the damage caused by blood borne contamination[U1]. BBB leakage occurs in a variety of neurological disorders such as Alzheimer’s disease.—In this study, researchers from the University of North Dakota School of Medicine and Health Sciences gave rabbits 3 mg caffeine each day — the equivalent of a daily cup of coffee for an average-sized person. The rabbits were fed a cholesterol-enriched diet during this time.—After 12 weeks a number of laboratory tests showed that the BBB was significantly more intact in rabbits receiving a daily dose of caffeine.—“Caffeine appears to block several of the disruptive effects of cholesterol that make the blood-brain barrier leaky,” says Jonathan Geiger, University of North Dakota School of Medicine and Health Sciences. “High levels of cholesterol are a risk factor for Alzheimer’s disease, perhaps by compromising the protective nature of the blood-brain barrier. For the first time we have shown that chronic ingestion of caffeine protects the BBB from cholesterol-induced leakage.”—Caffeine appears to protect BBB breakdown by maintaining the expression levels of tight junction proteins. These proteins bind the cells of the BBB tightly to each other to stop unwanted molecules crossing into the central nervous system.—The findings confirm and extend results from other studies showing that caffeine intake protects against memory loss in aging and in Alzheimer’s disease.—“Caffeine is a safe and readily available drug and its ability to stabilise the blood-brain barrier means it could have an important part to play in therapies against neurological disorders,” says Geiger.Journal reference: Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer’s disease Xuesong Chen, Jeremy W. Gawryluk, John F. Wagener, Othman Ghribi and Jonathan D. Geiger Journal of Neuroinflammation (in press)—Story Source: Adapted from materials provided by BioMed Central/Journal of Neuroinflammation
    Coffee Drinking Protects Against An Eyelid Spasm
    ScienceDaily (June 22, 2007) — People who drink coffee are less likely to develop an involuntary eye spasm called primary late onset blepharospasm, which makes them blink uncontrollably and can leave them effectively ‘blind’, according to a new study. —The effect was proportional to the amount of coffee drank and one to two cups per day were needed for the protective effect to be seen. The age of onset of the spasm was also found to be later in patient who drank more coffee — 1.7 years for each additional cup per day.—Previous studies have suggested that smoking protects against development of blepharospasm, but this Italian study did not show a significant protective effect. —Late onset blepharospasm is a dystonia in which the eyelid muscles contract uncontrollably; this starts as involuntary blinking but in extreme cases sufferers are rendered functionally blind despite normal vision because they are unable to prevent their eyes from clamping shut.—-The study involved 166 patients with primary late onset blepharospasm, 228 patients with hemifacial spasm (a similar muscle spasm that usually begins in the eyelid muscles but then spreads to involve other muscles of the face) and 187 people who were relatives of patients. The second two groups acted as controls.–The participants were recruited through five hospitals in Italy and asked whether they had ever drank coffee or smoked and for how many years. They were also asked to estimate how many cups of coffee they drank and/or packs of cigarettes they smoked per day. The age of onset of muscle spasms was recorded for patients who experienced them and a reference age was calculated for each of the patients’ relatives based on the duration of the spasms in the other group.—Regression analysis was used to observe the relationship between coffee drinking and smoking on the development of blepharospasm.—The authors say: ‘Our findings raise doubt about the association of smoking and blepharospasm but strongly suggest coffee as a protective factor.’ —‘The most obvious candidate for the protective effect is caffeine, but the low frequency of decaffeinated coffee intake in Italy prevented us from examining the effects of caffeine on blepharospasm. —They suggest that caffeine blocks adenosine receptors as has been proposed for its mechanism in protecting against Parkinson’s disease.—-The authors estimate that people need to drink one to two cups of coffee per day for the protective effect to be seen. ‘Considering that the caffeine content of a cup of Italian coffee (60–120 mg) is similar to the average content of a cup of American coffee (95–125 mg), the protective effect on the development of blepharospasm might be exerted at caffeine doses greater than 120–240 mg, comparable with the caffeine doses suggested to be protective in Parkinson’s disease,’ they say.—This research was published online ahead of print in the Journal of Neurology Neurosurgery and Psychiatry.—Story Source: Adapted from materials provided by BMJ Specialty Journals,
    Recipe for Coffee syrup—take ½ cup of instant coffee or grid down coffee bean of choice add to blender—-add brandy 1 oz ( white wine or red or even a cognac will be good as well ) add 6 squares of lindt cocoa or ¼ powder of cocoa Add 4 drops of the essential oil of peppermint—add 1 cup of honey half a cup at a time ( you will start with half a cup and then allow to liquefy and fuse the components once it is starting to fuse smoothly then add the other half while blending and blend this for a good 8 minutes at high speed—This will create a coffee syrup Then you can apply this as a flavouring agent in coffee or other beverages You will gain the antioxidant impact from the coffee –cocoa—and the peppermint—you will definitely feel more alert and feel an increase in oxygen uptake—slight stimulation—increase stamina—antioxidant—increase mental clarity ( removes the foggy effect )
    Caffeine in a Pill —You can as well use a caffeine pill but if you do use B5 and Taurine or even glycine and magnesium with this to offset any side effect the caffeine pill may bring ( not everyone reacts to caffeine so this is just a precautionary tidbit ) In either case do not mix with anything pharmaceutical unless you are aware of the impact or are trying to increase uptake on specific nutrients or remedies
    Muscle Loss in Elderly Linked to Blood Vessels’ Failure to Dilate
    ScienceDaily (May 20, 2010) — Why do people become physically weaker as they age? And is there any way to slow, stop, or even reverse this process, breaking the link between increasing age and frailty?—In a paper published online May 19 in the Journal of Clinical Endocrinology & Metabolism, University of Texas Medical Branch at Galveston researchers present evidence that answers to both those questions can be found in the way the network of blood vessels that threads through muscles responds to the hormone insulin.—Normally, these tiny tubes are closed, but when a young person eats a meal and insulin is released into the bloodstream, they open wide to allow nutrients to reach muscle cells. In elderly people, however, insulin has no such “vasodilating” effect.—“We were unsure as to whether decreased vasodilation was just one of the side effects of aging or was one of the main causes of the reduction in muscle protein synthesis in elderly people, because when nutrients and insulin get into muscle fibers, they also turn on lots of intracellular signals linked to muscle growth,” said UTMB’s Dr. Elena Volpi, senior author of the paper. “This research really demonstrates that vasodilation is a necessary mechanism for insulin to stimulate muscle protein synthesis.”—Volpi and her collaborators reached this conclusion after an experiment in which they infused an amount of insulin equivalent to that generated by the body in response to a single meal into the thigh muscles of two sets of young volunteers. One group had been given a drug that blocked vasodilation, while the other was allowed to respond normally. Measurements of muscle protein synthesis levels where made using chemical tracers, while biopsies yielded data on specific biochemical pathways linked to muscle growth.—“We found that by blocking vasodilation, we reproduced in young people the entire response that we see in older persons — a blunting of muscle protein response and a lack of net muscle growth. In other words, from a muscle standpoint, we made young people look 50 years older,” Volpi said.—Such results point the way to what could be a powerful new therapy for age-related frailty and the health and quality-of-life problems that come with it.—“Eventually, if we can improve muscle growth in response to feeding in old people by improving blood flow, then we’re going to have a major tool to reduce muscle loss with aging, which by itself is associated with reduction in physical functioning and increased risk of disability,” Volpi said.—Other authors of the paper were lead author and postdoctoral fellow Kyle Timmerman, medical student Jessica Lee, assistant professor Hans Dreyer, research scientist Shaheen Dhanani, graduate students Erin Glynn and Christopher Fry, assistant professor Micah Drummond, associate professor Melinda Sheffield Moore, and professor Blake Rasmussen. Specialized metabolic studies were conducted by the staff of the UTMB Clinical Research Center, part of the university’s Institute for Translational Sciences. The National Institute on Aging, the UTMB Claude D. Pepper Center Older Americans Independence Center, the National Institute of Child Health and Human Development and the UTMB Clinical Translational Sciences Award supported this study.— Story Source: Adapted from materials provided by University of Texas Medical Branch at Galveston, via EurekAlert!, a service of AAAS.
    Journal Reference:
    1. Kyle L. Timmerman, Jessica L. Lee, Hans C. Dreyer, Shaheen Dhanani, Erin L. Glynn, Christopher S. Fry, Micah J. Drummond, Melinda Sheffield-Moore, Blake B. Rasmussen, and Elena Volpi. Insulin Stimulates Human Skeletal Muscle Protein Synthesis via an Indirect Mechanism Involving Endothelial-Dependent Vasodilation and Mammalian Target of Rapamycin Complex 1 Signaling. Journal of Clinical Endocrinology & Metabolism,, May 19, 2010 DOI: 10.1210/jc.2009-2696
    [U1]Studies Verified not so much the cholesterol but the periodixzed cholesterol which is what actually causes lipofuscion a congesting of the brain with fats that are broken down