EK
My Comment Here—the issue is not about the estrogens and progesterones but rather the bodies ability to utilize them and remove them—the herbalist and other alternative health and healers knew this of yesteryear and would require women to do blood tonics and organ supporting herbs that would alleviate the load of these hormones—In todays times when foods consumed are highly hormonal –Soy – Vege oils ( estrogen imbalancing )-olive oils ( which can increase testosterone) peas ( estrogenic)– and chemicals that are highly xenoestrogenic like dish soaps and laundry soaps and cleaners and pesticide on or in the foods and hormone produced milk and meats—the system may not necessarily lack the gene but rather being so overwhelmed with the load that there is not enough to compensate for the imbalances—the old ways maybe tougher but the work –the thought and suggestions here would be to eliminate the foods causing the overload and to potential fast or reduce drastically consumption and increase foods that are going to reinforce the organs and the gene production to assist in balancing out what is overloaded
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Anti Estrogenic Antidote
Because of the overloading of the endocrine and lymphatic system of estrogen three has been a number of reproductive cancers occurring at a higher then normal rate…..if you look up the stats this didn’t happen til the 60’s when cancers of all types started to become more apparent in the USA and Canada…. What changed? The exposure to pesticides had definitely increased, the exposure to toxic pollutants had definitely increased, the removal of foods from the diet which were maligned to be a problem but in fact were not, and new food and dietary guidelines were introduced that were in fact cancer causing, such as soy and margarine, food additives and chemical preservatives, plastics that contained foods and detergents which are xeno-estrogenic characteristics. This means these are synthetic estrogens that will in fact react the same way as plant estrogens but in a higher concentrated levels that will bind to what are known as receptor sites ….these are areas of the body that are triggered by hormones and enzymes which cause a chemical reaction or trigger a signal in the body to perform whatever function that is required. These estrogens coming from with out, are extremely dangerous because of the way they accumulate in the body, and the reaction they cause in the body. In the case of estrogen it will lead to cancer, there are over 50 years of research an data to validate this, and to this day the end result has been the same since we have introduced highly estrogenic foods into the diet, males are becoming more mentally and physically dysfunctional, and women are breaking down more rapidly then there predecessors did. By being exposed to dish soap, latex, fuel oils, carpeting, clothing , fabric softeners, clothing made with synthethics, exhaust fumes from all petro products, including the Idea of biodiesel or bio fuels, this to will exacerbrate a bad condition already existing, and will compound the effect that much more…
So how do we heal this condition? How do we reverse the effect? Can we reverse the effect ?…there are herbs, supplements, and vitamins that actually regulate estrogen and remove the excess out of the body, via liver. And through other means of expulsion from the body. There are foods we can eat as well as foods to avoid that will assist us in the regulating of the overloading of the hormones in our system. I will give a list of foods herbs and supplements that will assist in this endeavor to keep us hormonally balanced :….Some of these will be used as a tea, others will be consumed and others used as a supplement….and in some cases used together to remove whatever is afflicting us hormonally….
Vitamins:
Zinc
Iodine
Selenium
Magnesium
Sulfur
Herbs that can assist in the removal of estrogen from the body
Watercress
Turmeric
Garlic
Onion
Shallots
Parsely
Mint
Celery Root
Rosemary
Siberian Ginseng
Gota Kola
Thyme
Milk Thistle
Dandelion
Lady’s Thistle
Summer and Winter Savoury
Ginger and Galangal
Balm of Gilead ( balsam poplar )
Perilla
Olive Leaf
Oregano
Supplements that will remove estrogen or block it’s effect
NAC
L Cysteine
Methionine
Taurine
Foods that can remove or block estrogen:
Nuts
Seeds
Omega 9 oils
Avocado
Rice Bran Oil
Wheat Germ Oil
Papaya
Pineapple
Berries
Citrus fruits ( Bioflavonoids )
Oats and Barley ( Whole )
Broccoli and Broccoli Sprouts
Onion Sprouts
Cabbage
Cauliflower
Kohl Rabi
Kale
Parsley
Celery Root
Grass fed Animals ( grain fed will encourage hormone imbalancing due to the excess of omega 6 in the fat rather then 3 ( grass fed cows have 15 times more omega 3 then fish )
Ocean caught fish ( make sure you increase garlic or sulfur based supplement with Vitamin C to offset any potential mercury or lead poisoning of the fish.
Ground flax seed ( due to the fibre content of the lignans which will bind to the estrogens ) Make sure you grind it fresh not store bought
Herbal Teas
Any tea that will support the liver and the endocrine system should be used to assist in the removal of any unwanted toxin or increase the antioxidant levels so that the body is able to be more efficient in the removing of unwanted pathogens or hormones
Schizandra berry
Fo Ti Eng
Rehmannia Root
Jiagolan
Milk thistle
Nettle
Dandelion
Burdock
Sarsparilla
Perilla
Parsley
White Pine
Birch
Siberian ginseng
Self Heal
Make sure all teas are drunk without any processed sugar or artificial sweetners…Use Xylitol from birch trees or Unpasteurized honey
®®RAW MILK ( not pasteurized ) due to the CLA and Vitamin D content
®®Grass fed Cow’s Butter
®®Seed and Nut Milk
®®Almonds ( due to the phosphorous in it to assist the liver in detoxing the estrogens out)
®®Walnuts ( omega 3 which block estrogen conversion of omega 6 )
®®Pumpkin Seed ( due to the zinc content in regulating hormones )
http://augmentinforce.50webs.com/ANTI%20ESTROGEN%20SOLUTIONS.htm#ANTI ESTROGEN SOLUTIONS
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[U1]Let’s take a look here, there is an issue with this conclusion—see they did a calorie restricted diet has nothing to do with fat or protein or carb or even other nutrients –calorie restricted —this implies a reduction in everything—so the misleading end of this is to get the reader to see that it is FAT that is the problem—it may very well be —but NOT NECESSARILY–what usually triggers the IGF is sugar ( which increases insulin ) and proteins ( arginine-aspartic acid–precursors to GH and whey protein–not to mention zinc-magnesium-and potassium )—the point here is that IGF is as well utilized to break down fatty acids as well—so again in these type of article pay attention to how they will show you a specific but then lead you to a bad conclusion!!
[U2]21 pounds in 5 weeks is about all anyone should be losing in this time frame–the avg lost should be about 3lbs per week anything more can be a rebounder—it can come back and with more pounds as well–this was avg just over 4 .2 lbs
[U3]Again look at this comment here—we eat to much fatty foods—what FAT—since we have an abundant of choices here –vegetable oils ( soy) canola oils -margarines-fih oils with mercury–these are fats as well and People do consume alot of these as well—and then end result is always illnesss the FAT that they are talking is which one?? and can they then explore is it the fat or the components in the fats which maybe the culprit? again see this for what it is —
[U4]Hmm seems to me that the energy of source for the body isssssss F-A-T
[U5]This maybe the resolution to getting rid of the fat storage or to increase fat efficiency getting Bile salts
[U6]Coenzyme A combines with Acetic Acid (derived from endogenous Pyruvic Acid) to form Acetyl Coenzyme A.
Nucleic Compounds–Coenzyme A facilitates the repair of the body’s endodgenous Deoxyribonucleic Acid (DNA).-Coenzyme A facilitates the repair of the body’s endodgenous Ribonucleic Acid (RNA).
These Substances Enhance the Function of Coenzyme A–Amino Acids-By exchanging across sub-cellular membranes, Acetyl-L-Carnitine (ALC) serves as a pool of acetyl groups to regenerate Acetyl-Coenzyme A from free Coenzyme A.
Lipids–Caprylic Acid is rapidly reduced to Coenzyme A in the Liver.
Vitamins–Metabolites of Vitamin B5 (in its Pantethine form) are essential components of the Coenzyme A molecule
[U7]Interpret this accurately they are not saying you will not get cancer using estrogen but you will get it more then likely if combining this with progesterone or it’s synthethic progestrin—so in other word we are overloading these receptor sites with an already overloaded system and the genes that regulate these hormones are either inadequate or are not present—so then the alternative would be to reduce the overload-not increase the hormones—by blocking the receptors with more hormones all that is happening is a delaying of a cancer nothing more
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Show of the Week January 24- 2011
99% of Pregnant Women in US Test Positive for Multiple Chemicals Including Banned Ones-Research
Dangerous Antidepressants
OAT VINEGAR
Recipe for Oat Vinegar
Vinegar
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99% of Pregnant Women in US Test Positive for Multiple Chemicals Including Banned Ones-Research
ScienceDaily (Jan. 16, 2011) — The bodies of virtually all U.S. pregnant women carry multiple chemicals, including some banned since the 1970s and others used in common products such as non-stick cookware, processed foods and personal care products, according to a new study from UCSF. The study marks the first time that the number of chemicals to which pregnant women are exposed has been counted.–Analyzing data for 163 chemicals, researchers detected polychlorinated biphenyls (PCBs), organochlorine pesticides, perfluorinated compounds (PFCs), phenols, polybrominated diphenyl ethers (PBDEs), phthalates, polycyclic aromatic hydrocarbons (PAHs) and perchlorate in 99 to 100 percent of pregnant women. Among the chemicals found in the study group were PBDEs, compounds used as flame retardants now banned in many states including California, and dichlorodiphenyltrichloroethane ( DDT), an organochlorine pesticide banned in the United States in 1972.—Bisphenol A (BPA), which makes plastic hard and clear, and is found in epoxy resins that are used to line the inside of metal food and beverage cans, was identified in 96 percent of the women surveyed. Prenatal exposure to BPA has been linked to adverse health outcomes, affecting brain development and increasing susceptibility to cancer later in life, according to the researchers. Findings will be published in Environmental Health Perspectives on Jan. 14. The study was not designed to identify direct connections to adverse health outcomes.”It was surprising and concerning to find so many chemicals in pregnant women without fully knowing the implications for pregnancy,” said lead author Tracey Woodruff, PhD, MPH, director of the UCSF Program on Reproductive Health and the Environment.—“Several of these chemicals in pregnant women were at the same concentrations that have been associated with negative effects in children from other studies. In addition, exposure to multiple chemicals that can increase the risk of the same adverse health outcome can have a greater impact than exposure to just one chemical,” said Woodruff, an associate professor in the UCSF Department of Obstetrics and Gynecology and Reproductive Sciences.–Exposure to chemicals during fetal development has been shown to increase the risk of adverse health consequences, including preterm birth and birth defects[U1], childhood morbidity, and adult disease and mortality according to the research team. In addition, chemicals can cross the placenta and enter the fetus,[U2] and in other studies, a number of chemicals measured in maternal urine and serum have been found in amniotic fluid, cord blood and meconium, they state.–The researchers analyzed data for 268 pregnant women from the National Health and Nutritional Examination Survey (NHANES) 2003-2004, a nationally representative sample of the U.S. population.–“Our findings indicate several courses of action. First, additional research is needed to identify dominant sources of exposure to chemicals and how they influence our health, especially in reproduction,” said Woodruff. “Second, while individuals can take actions in their everyday lives to protect themselves from toxins, significant, long-lasting change only will result from a systemic approach that includes proactive government policies.[U3]”–Co-authors of the study are Ami R. Zota and Jackie M. Schwartz of the Program on Reproductive Health and the Environment, UCSF Department of Obstetrics and Gynecology and Reproductive Sciences.–Funding for the study was provided by the Pew Charitable Trusts and a grant from the Passport Science Innovation Fund.–Story Source–The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of California – San Francisco.–Journal Reference–Tracey J. Woodruff, Ami R. Zota, Jackie M. Schwartz. Environmental Chemicals in Pregnant Women in the US: NHANES 2003-2004. Environmental Health Perspectives, 2011; DOI: 10.1289/ehp.1002727 —
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Dangerous Antidepressants
The Institute for Safe Medication Practices (ISMP) recently published a study in the journal PLoS One highlighting the worst prescription drug offenders that cause patients to become violent.
Among the top-ten most dangerous are the antidepressants Pristiq (desvenlafaxine), Paxil (paroxetine) and Prozac (fluoxetine).
Concerns about the extreme negative side effects of many popular antidepressant and antipsychotic drugs have been on the rise, as these drugs not only cause severe health problems to users, but also pose a significant threat to society. The ISMP report indicates that, according to the U.S. Food and Drug Administration’s (FDA) Adverse Event Reporting System, many popular drugs are linked even to homicides.
Most of the drugs in the top ten most dangerous are antidepressants, but also included are an insomnia medication, an attention-deficit hyperactivity disorder (ADHD) drug, a malaria drug and an anti-smoking medication.
As reported in Time, the top ten list is as follows:
[10.] Desvenlafaxine (Pristiq) – An antidepressant that affects serotonin and noradrenaline. The drug is 7.9 times more likely to be associated with violence than other drugs.
[9.] Venlafaxine (Effexor) – An antidepressant that treats anxiety disorders. The drug is 8.3 times more likely to be associated with violence than other drugs.
[8.] Fluvoxamine (Luvox) – A selective serotonin reuptake inhibitor (SSRI) drug that is 8.4 times more likely to be associated with violence than other drugs.
[7.] Triazolam (Halcion) – A benzodiazepine drug for insomnia that is 8.7 times more likely to be associated with violence than other drugs.
[6.] Atomoxetine (Strattera) – An ADHD drug that is 9 times more likely to be associated with violence than other drugs.
[5.] Mefoquine (Lariam) – A malaria drug that is 9.5 times more likely to be associated with violence than other drugs.
[4.] Amphetamines – This general class of ADHD drug is 9.6 times more likely to be associated with violence than other drugs.
[3.] Paroxetine (Paxil) – An SSRI antidepressant drug that is 10.3 times more likely to be associated with violence than other drugs. It is also linked to severe withdrawal symptoms and birth defects.
[2.] Fluoxetine (Prozac) – A popular SSRI antidepressant drug that is 10.9 times more likely to be associated with violence than other drugs.
[1.] Varenicline (Chantix) – An anti-smoking drug that is a shocking 18 times more likely to be associated with violence than other drugs.
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OAT VINEGAR ( WILD OAT )
BACKGROUND: The present study focused on the antioxidant activities of aged oat (Avena sativa L.) vinegar. The antioxidant activities of oat and vinegar have been proved by many previous research studies. It should be noted that oat vinegar, as a novel seasoning, has antioxidant activity.
RESULTS: Oat vinegar showed stronger radical scavenging activities, reducing power, and inhibition of lipid peroxidation than rice vinegar. The concentrations of polyphenols and flavonoids in oat vinegar were higher than those in rice vinegar. Ethyl acetate extract of oat vinegar possessed the most varieties of phenolic acids and showed the strongest antioxidant activity compared with ethanol and water extracts. At suitable doses of oat vinegar, the malondialdehyde value was decreased, activities of superoxide dismutase and glutathione peroxidase were promoted, and hepatic damage induced by (60)Co gamma-irradiation was ameliorated in aging mice.
CONCLUSION: Oat vinegar manifested antioxidant activity which was stronger than that of rice vinegar in vitro and the same as that of vitamin E in vivo.
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Antioxidant capacity of oat (Avena sativa L.) extracts. 2. In vitro antioxidant activity and contents of phenolic and tocol antioxidants.
Emmons CL, Peterson DM, Paul GL.
Cereal Crops Research Unit, Agricultural Research Service, U.S. Department of Agriculture, 501 Walnut Street, Madison, Wisconsin 53705, USA.
Abstract
Oat milling fractions were examined for concentrations of total phenolics, tocols, and phenolic acids and in vitro antioxidant activity to determine their potential as dietary antioxidants. Methanolic extracts of pearling fractions, flour and aspirations from flaking, and trichomes had high, intermediate, and low antioxidant activities, respectively, evaluated by the beta-carotene bleaching method. Pearling fractions were also highest in total phenolics and tocols. p-Hydroxybenzoic acid, vanillic acid, caffeic acid, vanillin, p-coumaric acid, and ferulic acid were identified and quantified by HPLC. Three avenanthramides and an unidentified ferulate derivative were also detected. Total phenolic content was significantly correlated with antioxidant activity, and regression equations that predicted antioxidant activity from phenolic and tocol concentrations were calculated. Antioxidant activity, evaluated by beta-carotene bleaching, was correlated with measures of oxygen radical absorbance capacity and low-density lipoprotein oxidation. These data indicate a potential for oat products, especially those enriched in outer layers of the groat, to contribute to dietary intakes of -antioxidant phytonutrients.
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Potential health benefits of Wild Oats antioxidants avenanthramides
Meydani M.
Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. [email protected]
Abstract
Oats are known to be a healthy food for the heart due mainly to their high beta-glucan content. In addition, they contain more than 20 unique polyphenols, avenanthramides, which have shown strong antioxidant activity in vitro and in vivo. The polyphenols of oats have also recently been shown to exhibit anti-inflammatory, antiproliferative, and anti-itching activity, which may provide additional protection against coronary heart disease, colon cancer, and skin irritation.–PMID: 19941618 [PubMed – indexed for MEDLINE]
CRecipe for Oat Vinegar—add a cup of groats ( oats with the shell ) in a jar and add vinegar to this and let sit for 10 days on a fridge—this will have fermented the grain with all of it’s content) strain and pour rest into a GLASS container and use as a vinegar on salads or even straight up as a tonic or antioxidant aid
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Vinegar
Can be made from any liquid that is capable of being converted into alcohol in a two-step process. The fruit juice or other liquid contains sugar, which is converted into alcohol and carbon dioxide gas by the actions of yeast enzymes. The alcohol thus formed combines with atmospheric oxygen by the action of Acetobacter bacteria, forming acetic acid and water. Organic acids and esters derived from the fruit or other source material are also present and are responsible for the flavour and aroma variations of vinegar. Table vinegar contains approximately 4 percent acetic acid. These bacteria work together symbiotically, producing enough acetic acid to prevent invasion by other organisms.–Despite its ancient origin, the technology of vinegar production advanced slowly, improvements consisting principally of better methods of aeration. The Orleans process, best-known of the old methods, used a barrel of about 50 gallons (200 l) capacity. A mash consisting of wine or other alcoholic liquid was poured into the barrel, and a small amount of vinegar containing a mass of vinegar bacteria, called mother of vinegar, was added to start the reaction. One or two small air holes drilled above the liquid level exposed the surface to aeration. The finished vinegar was drawn off through a wooden spigot near the bottom. Care was taken in refilling the barrel with the new charge of raw ingredients to avoid breaking up the surface film of bacteria.—Early in the 18th century, a Dutch technologist, Hermann Boerhaave, found that the rate of acid production in the vinegar process was directly proportional to the amount of surface exposed to air. Thus, subsequent methods attempted to introduce more air into the casks. In the 20th century, continuous aeration—air bubbles pumped through the mash—was developed.–Vinegar’s principal uses are the flavouring of foods and the preservation, or pickling, of meat products, fish, fruit, and vegetables. For use as a condiment, vinegar is often flavoured with garlic, onions, tarragon, or other herbs and spices. Mixed with oil and seasonings it becomes a classic cold sauce—vinaigrette—used as a dressing on vegetable salads and served as a sauce with cold cooked vegetables, meats, and fish. Vinegar is also a common ingredient in marinades and is widely used in the pickling of cucumbers and other vegetables.
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[U1]NOWWWWW you have to ask the Question the big one, Why are women getting Vaccinated and or the children or Fetuses in the womb, woman are being purposely infected???? and a MULTITUDE OF CHEMICALS WILL INCREASE ADVERSE HEALTH OUTCOMES????!!!!! DING DING DING –Are We seeing This!!!
[U2]Is this what we want —A violation of fetal Life by having this cross through the placenta!!
[U3]This should not be allowed in the Gov’t’s hands at all—this should be with those of us who have a geniune interest in preerving the Human Race from Gov’t who can easily be bought out by Special interest who mass produce thes toxic waste as well as those who would infect the populace with more infectious disease–the Gov’t has no credibility NONE!!
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Show of the Week Jan 28- 2011
Obamacare Bill suggests data chip implants
Montrealers Are Feeding Fish Prozac- Research Shows Influence on Brain Activity While Long-Term Consequences Are Unclear
CRN– IND guidance could run against spirit of DSHEA–Article 13 American Style
Inflammation and Headache Recipes
Council for Responsible Nutrition, Washington, DC
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Obamacare Bill suggests data chip implants
Coverage under Obamacare will require an implantable microchip.
There’s a pretty starling thing in the bill that 95% of Americans won’t like.
The Obama Health care bill under Class II (Paragraph 1, Section B) specifically includes ‘‘(ii) a class II device that is implantable.” Then on page 1004 it describes what the term “data” means in paragraph 1, section B:
14 ‘‘(B) In this paragraph, the term ‘data’ refers to in
15 formation respecting a device described in paragraph (1),
16 including claims data, patient survey data, standardized
17 analytic files that allow for the pooling and analysis of
18 data from disparate data environments, electronic health
19 records, and any other data deemed appropriate by the
20 Secretary”
What exactly is a class II device that is implantable?
Lets see…
Approved by the FDA, a class II implantable device is a “implantable radiofrequency
transponder system for patient identification and health information.” The purpose of a class II device is to collect data in medical patients such as “claims data, patient survey data, standardized analytic files that allow for the pooling and analysis of data from disparate data environments, electronic health records, and any other data deemed appropriate by the Secretary.”
This sort of device would be implanted in the majority of people who opt to become covered by the public health care option. With the reform of the private insurance companies, who charge outrageous rates, many people will switch their coverage to a more affordable insurance plan. This means the number of people who choose the public option will increase. This also means the number of people chipped will be plentiful as well. The adults who choose to have a chip implanted are the lucky (yes, lucky) ones in this case. Children who are “born in the United States who at the time of birth is not otherwise covered under acceptable coverage” will be qualified and placed into the CHIP or Children’s Health Insurance Program (what a convenient name). With a name like CHIP it would seem consistent to have the chip implanted into a child. Children conceived by parents who are already covered under the public option will more than likely be implanted with a chip by the consent of the parent. Eventually everyone will be implanted with a chip. And with the price and coverage of the public option being so competitive with the private companies, the private company may not survive.
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Montrealers Are Feeding Fish Prozac; Research Shows Influence on Brain Activity While Long-Term Consequences Are Unclear
ScienceDaily (Jan. 22, 2011) — Around one in four Montrealers take some kind of anti-depressant, and according to new research, the drugs are passing into the waterways and affecting fish.–The findings are internationally significant as the city’s sewage treatment system is similar to that in use in other major cities, and moreover, it is reputed to be the third largest treatment system in the world. Lead by Dr. Sébastien Sauvé at the University of Montreal’s Department of Chemistry and André Lajeunesse, a PhD candidate, the research team found that the drugs accumulate in fish tissues and are affecting the fish’s brain activity.—The Saint Lawrence is a major international waterway that connects the Atlantic Ocean to the Great Lakes, and it surrounds the island of Montreal. Sauvé has been looking at the chemical pollution of the water system for years. “Montreal has a very basic sewage system — the city basically only removes solids, there’s no disinfecting of the water,” he explained. “In any case, the chemical structure of anti-depressants makes them extremely difficult to remove from sewage, even with the most sophisticated systems available.”–“We know that antidepressants have negative side effects on human beings,” Sauvé said, “but we don’t know how exactly how these chemicals are affecting the fish, and by extension, the Saint Lawrence River’s ecosystem.” Despite a lack of information about the possible toxicity brought from these substances, the research group suggests an interesting tool to track the early biological effects of antidepressants. “Since the acute toxicity of antidepressants is less probable toward aquatic organisms, chronic toxicity remained possible. In this way, the suggested biomarker involved in the serotonin regulation in the brain may represent a promising means of determining subtle biological effects to fish,” explained Lajeunesse. Chronic toxicity means harm resulting from long-term exposure, whereas acute relates to more immediate harm following a single high-dose incident. Serotonin is an important chemical that plays a role in feelings of happiness — it’s sometimes referred to as the “happy hormone.”–Sauvé was quick to point out that there is no immediate danger to humans. “The amount of anti-depressants being released into our river works out to roughly the equivalent of a grain of salt in an Olympic-size swimming pool,” he said. “That’s not enough to affect people, should they are brave enough to go fishing out there — I’d be more worried about the trace metals! Nevertheless, we are seeing an impact on the river’s ecosystem, which should concern cities everywhere.” Further research by other teams will look at exactly what the consequences might be.–This research received funding from the Chemical Management Plan — Health Canada, the St. Lawrence Action Plan and the Canadian Foundation for Innovation. It was published online by Chemosphere on Jan. 5, 2011. Christian Gagnon, François Gagné, and Séverine Louis at Environment Canada and Patrick Čejka at the Montreal Sewage Treatment Plant contributed to the findings.
Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of Montreal, via EurekAlert!, a service of AAAS.-Journal Reference-André Lajeunesse, Christian Gagnon, François Gagné, Séverine Louis, Patrick Čejka, Sébastien Sauvé. Distribution of antidepressants and their metabolites in brook trout exposed to municipal wastewaters before and after ozone treatment – Evidence of biological effects. Chemosphere, 2011; DOI: 10.1016/j.chemosphere.2010.12.026
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CRN– IND guidance could run against spirit of DSHEA–Article 13 American Style
As the Food and Drug Administration (FDA) prepares final guidance on Investigational New Drugs (INDs) a leading trade group has warned of the damaging effect on nutrient research that could follow if the application of INDs is not modified from the current draft guidance.
The Washington DC-based Council for Responsible Nutrition (CRN) submitted comments to the FDA highlighting why nutrient research could sometimes be applied in both the pharma and food spheres.–A demarcation between the two would defeat the intention of the 1994 Dietary Supplement and Health Education Act (DSHEA), it said, and called for certain types of research o be exempt from NDI requirements.
“While CRN agrees that a product’s intended use should dictate its regulatory category, we question the rationale for allowing a product’s regulatory category to drive scientific inquiry,” the CRN’s vice president of scientific and regulatory affairs, Duffy MacKay wrote in a nine-page submission.
MacKay wrote his group was concerned, “some aspects of the Draft Guidance may have the unintended consequence of acting in opposition to the spirit” of DSHEA, and create, “unnecessary obstacles to the continued scientific study of dietary supplements.”
He added that DSHEA had authorized the establishment of the Office of Dietary Supplements (ODS) at the National Institutes of Health (NIH) to study the benefits of dietary supplements in maintaining health and preventing chronic disease and so ‘dietary supplements’ had been mandated to be studied in a pharma and nutra ways.
“The potential for a dietary supplement to have a dual definition, which is dependent on its intended use, has resulted in much confusion amongst the research community.”
Nutrients versus drugs
Industry is concerned some nutrients like omega-3s or probiotics may require IND’s if they are to be studied, and that there will be a bias to disease endpoints as there are no validated endpoints for wellness.
“For example, an investigator interested in evaluating a yogurt product from the grocery store that contains beneficial bacteria for its ability to prevent constipation in a healthy population would be required to file an IND. This seems incongruent with the intent of the IND…”
MacKay highlighted further clarity was needed because:
· Much nutrient research was academia, not commercial driven and academia need to be alerted to the guidance and its implications for their work, especially when an IND is required.
· Cost and proprietary science concerns would see companies pulling out of the scientific process if INDs are required for certain trials.
· IND approaches across various sectors are not unified and an IND policy in the Center for Food Safety and Applied Nutrition (CFSAN). The current system may see an inundation of INDs.
· Many nutrients possess a variability that does not fit the IND model.
· Obtaining an IND does not necessarily improve study safety or quality.
He pointed out a grey area in that DSHEA does not permit a, “product that does not contain an article authorized for investigation as a new drug, antibiotic, or biological for which substantial clinical investigations have been instituted and for which existence of such investigations has been made public.”
But the FDA has indicated a citizen’s petition, such as the one currently being appraised for a hormone produced by Canadian firm Ovos Natural Health, could be a way to have nutrients that have been subject to drug research classified as dietary supplements, via the New Dietary Ingredients route.
MacKay called for the FDA to specify financial penalties for conducting trials without INDs.
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Inflammation and Headache Recipes
Headaches—Body aches—Aches in places where you have aches
Lets make a remedy—Lets start out with something conventional and give it a boost
Aspirin 81 mg or a generic that is 81mg –Uneneterocoated—1 caplet with with 100-200 mgs of magnesium and 1/8 tsp of cayenne pepper or 1 capsule at 500mgs—take together
Take White Willow Extract or tincture put into a glass container and add 1 ½ oz to ½ oz of cayenne tincture—Mix Well and then take ¼-1/2 tsp
Dlpa 500 -750 mgs with 200 mgs of magnesium citrate
Bay Leaf Extract with Cayenne Pepper 1:1 ratio ( equal parts say ½ oz to a ½ oz ) mix well and take ¼ -1/2 tsp
White Willow or FeverFew 1/8 cup with 6-8 leaves of Bay Leaf in a 2 pint pot of water—drink a 4-6 oz serving several times a day
Breatheing in the Essential oil of lavender
Body Ache
Using Vicks as a body Rub or make your own cream by adding Peppermint 8 drops—Camphor 8 drops —Eucalyptus 8 drops and Wintergreen 8 drops with a red or black pepper extract 1 oz and fuse in bees wax and coconut oil ½ cup of coconut oil and ¼ cup of wax or less if you want a lotion –add 1 oz of alcohol and heat together in a double broiler or a ban marie heat til all soft –wne at this point then take a blender and pour content in glass container—allow for cooling then apply this liberally and even on chest cavity for congestion the apply this where pain exist
Using Pine oil 4 drops and Camphor oil 4 drops and mix with 4 oz of peanut oil and massage in pained areas or areas of intense out break
Take a bath in Magnesium sulfate or magnesium chloride1 cup per bath –will alleviate pain
Some of these can apply to menstrual pain as well—body aches—prostrate inflammation—leg problems—circulatory problems—muscle joint pain Back aches and the list goes on
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Show Of the Week January 31- 2011
Nutrients that can Induce Sleep
Some things that can carry Melatonin
Tryptophan (Trp) Content of Various Foods
Stages of Sleep
Nutrients That Can Induce Sleep
5-HTP (5-Hydroxytryptophan) increases total Sleep time.
Acetyl-L-Carnitine improves the quality of Sleep and reduces the optimal number of hours of Sleep required.
Phenylalanine reduces the amount of Sleep time required.
Tryptophan (500 – 4,000 mg per night) reduces the amount of time taken to fall asleep (Sleep latency) when taken one to two hours prior to retiring.
Antioxidants—Butylated Hydroxytoluene (BHT) reduces the amount of Sleep time that is required for optimal health.
Hormones—-Supplemental, exogenous Dehydroepiandrosterone (DHEA) (50 mg per day) improves the quality of Sleep (especially in people aged 40 and over).
Human Growth Hormone (hGH) helps to regulate and facilitate Sleep:
Endogenous hGH is released during Slow-Wave Sleep and helps to regulate REM Sleep. Exogenous, supplemental hGH has been demonstrated to restore Slow-Wave Sleep and REM Sleep patterns to normal. Supplemental, exogenous Melatonin decreases the relative proportion of the Drowsiness and Stage 1 Sleep and increases the relative proportion of Stage 2, Slow-Wave and Rapid Eye Movement Sleep Supplemental Melatonin greatly reduces the number of movements during Sleep, reduces the time taken to fall asleep after retiring (Sleep latency), reduces the body’s core temperature during Sleep and improves the subjective quality of Sleep without increasing next-morning Drowsiness.
Progesterone helps to restore normal Sleep cycles.
Exogenous Vasopressin improves the quality of Sleep, increases total Sleep time and increases the quantity of Slow-Wave Sleep.
Lipids
Exogenous Prostaglandin D2 (PGD2) infused into the Cerebral Ventricles (in a clinical setting) induces natural Sleep.
Minerals
Magnesium (when consumed just prior to retiring) improves the quality of Sleep. Potassium improves the quality of Sleep and reduces the frequency of awakenings after the onset of Sleep.
Neurotransmitters
Acetylcholine helps to maintain Sleep. It controls the amount of sensory input that reaches the Brain during Sleep and increases the stimulus barrier (increasing the threshold of sensory inputs before wakiing occurs) during Sleep. Optimal Acetylcholine allows sleepers to remain asleep through minor noises and other disturbances. Light sleepers are likely to have sub-optimal Acetylcholine.
Supplemental, exogenous Gamma Aminobutyric Acid (GABA) (1,000 – 3,000 mg administered sublingually at night) facilitates Sleep. research
Smart Drugs
Diapid alleviates some Sleep disorders.
Dimethylaminoethanol (DMAE) reduces the amount of Sleep required by approximately one hour per night (this effect occurs after six weeks of continuous DMAE use):
DMAE makes it easier for most people to get fall asleep Sleep at night.
DMAE users experience a sounder Sleep and after six weeks of continuous DMAE use, most people report waking earlier and having a clearer mind upon waking.
Gamma-Hydroxybutyrate (GHB) facilitates both Rapid Eye Movement (REM) Sleep and Slow-Wave (deep or non-REM) Sleep. research
Minaprine improves the quality of Sleep (when taken early in the day):
Minaprine users report awakening with reduces tiredness in the morning.
Caution: Minaprine should not be consumed at night as it can prevent Sleep.
Vitamins
Choline improves the quality of Sleep. It helps to keep an individual asleep after they have fallen asleep (via its role as a precursor for Acetylcholine, the Neurotransmitter that helps to prevent unnecessary interruptions to Sleep from non-threatening stimuli).
Inositol (1,000 – 10,000 mg taken at bedtime) improves the quality of Sleep (by assisting Vitamin B3 to bind to the Benzodiazepine Receptors in the Brain).
Vitamin B3 (200 – 1,000 mg of the Niacinamide form of Vitamin B3 taken at bedtime) improves the quality of Sleep (by binding to the Benzodiazepine Receptors of the Brain).
Vitamin B6 improves the quality of Sleep (by functioning as a cofactor for the production of Serotonin).
Vitamin B12 improves the quality of Sleep (by increasing endogenous Melatonin levels early in the night and reducing Melatonin levels at then end of a night’s Sleep).
Vitamin E improves the quality of Sleep.
These Foods/Herbs Improve the Quality of Sleep
Fruits—Grapefruit (juice consumed at night) improves the quality of Sleep.
Herbs—-Astragalus improves the quality of Sleep (it has been demonstrated to increase Sleep time in animal studies).
Catuaba reputedly improves the quality of Sleep.
Damiana helps some people to Sleep better (according to anecdotal reports).
Essiac (a mixture of Herbs – primarily Sheep Sorrel) improves the quality of Sleep (according to anecdotal reports).
Ginkgo biloba rectifies impaired Sleep quality in persons using Tricyclic Antidepressants and may also improve Sleep quality in normal, healthy persons: Ginkgo biloba reduces the duration of Stage 1 Sleep in persons using Tricyclic Antidepressants and may also reduce the duration of Stage 1 Sleep in normal, healthy persons. Ginkgo biloba enhances the quality of Slow-Wave Sleep (deep Sleep) in persons using Tricyclic Antidepressants and may also enhance the quality of Slow-Wave Sleep in normal, healthy persons.
Lavender (oil used in Aromatherapy) and tincture or tea improves the quality of Sleep.
Passion Flower induces a restful Sleep free from frequent awakenings and disturbances (by means of its constituent Harmala Alkaloids sedating the Central Nervous System).
Siberian Ginseng normalizes Sleep patterns.
Valerian improves the quality of Sleep.
Vanillin or Vanilla assist in the relaxation and inducing of sleep
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Recipes for Sleep—Glycine 500mgs + Inositol 500mgs 30 min before bed
Taurine 500mgs + magnesium—Gaba 500mgs + Niacinamide 250-500mgs
Melatonin- Trytophan 500mgs + Niacin 50 mgs Vanilla 10 drops + Lavender tincture 10 drops in 2 oz of water—Passion flower 10 drops + St John’s wort
Valerian tincture + Passion Flower10 drops of each in water—Utilize an of these combinations 30 minutes before going to bed and do not Mix Under any circumstance with anything from the pharmacy that is drug related
Some things that can carry Melatonin
Melatonin: Natural food and non-food sources of melatonin
Melatonin is a molecule synthesized in the brain by the pineal gland and in the gastrointestinal tract. Melatonin is also synthesized in other organisms including plants.
Melatonin is believed to be responsible for the synchrony of circadian rhythm, modulating sleep patterns with day and night.
Melatonin is an antioxidant and protects tissues from oxidative damage by free radical elements. Further more, melatonin induces synthesis of endigenous antioxidants such as superoxide dismtase (SOD).
Several researches indicate that melatonin protects the gastrointestinal tract from irritation, reduces stress-induced lesion formation and heals ulcer.
Below are lists containing natural plant sources of melatonin. Melatonin content is in nanogram (ng) per gram of plant sample