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Immunostimulatory effect of Silybum Marianum (milk thistle) extract.
Wilasrusmee C, Kittur S, Shah G, Siddiqui J, Bruch D, Wilasrusmee S, Kittur DS.
Source–Department of Surgery SUNY Upstate Medical University, Syracuse, New York 13210, USA. [email protected]
BACKGROUND–Herbal products are increasingly used for their effects on the immune system. Milk Thistle, a commonly used herbal product is known to inhibit growth of certain tumors, although the mechanism of this effect remains unknown. Previously we have shown that Milk Thistle extracts stimulate neurons in culture. Since other drugs that affect the neuronal; system also affect the immune system, we investigated the effects of Milk Thistle on the immune system.–MATERIAL/METHODS-Standardized Milk Thistle extract was studied in murine lymphocyte proliferation tests using Concanavalin A (ConA) as mitogen for non-specific stimulation and mixed lymphocyte culture (MLC) as allospecific stimulation. Th1 and Th2 cytokine levels in MLC were assayed by two antibody capture ELISA technique. All tests were performed in triplicate and repeated twice.—RESULTS-We found that Milk Thistle is immunostimulatory in vitro. It increased lymphocyte proliferation in both mitogen and MLC assays. These effects of Milk Thistle were associated with an increase in interferon gamma, interleukin (IL)-4 and IL-10 cytokines in the MLC (table). This immunostimulatory effect increased in response to increasing doses of Milk Thistle.—CONCLUSIONS-Our study has uncovered a novel effect of milk thistle on the immune system. This immunostimulatory effect may be of benefit in increasing the immunity to infectious diseases.–PMID-12444368-[PubMed – indexed for MEDLINE]
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Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.).
Tamayo C, Diamond S.
Source–Research and Development at Flora Inc, Bethesda, MD 20817, USA. [email protected]
Abstract–Milk thistle extracts have been used as traditional herbal remedies for almost 2000 years. The extracts are still widely used to protect the liver against toxins and to control chronic liver diseases. Recent experimental and clinical studies suggest that milk thistle extracts also have anticancer, antidiabetic, and cardioprotective effects. This article reviews clinical trials of milk thistle conducted in the past 5 years including pharmacokinetic and toxicity studies, herb-drug interactions, and other safety issues. Several trials have studied the effects of milk thistle for patients with liver diseases, cancer, hepatitis C, HIV, diabetes, and hypercholesterolemia. Promising results have been reported in the protective effect of milk thistle in certain types of cancer, and ongoing trials will provide more evidence about this effect. In addition, new established doses and improvement on the quality and standardization of this herb will provide the much-awaited evidence about the efficacy of milk thistle in the treatment of liver diseases. Milk thistle extracts are known to be safe and well tolerated, and toxic or adverse effects observed in the reviewed clinical trials seem to be minimal. The future of milk thistle research is promising, and high-quality randomized clinical trials on milk thistle versus placebo may be needed to further demonstrate the safety and efficacy of this herb.-PMID-17548793-[PubMed – indexed for MEDLINE]
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The potential of milk thistle (Silybum marianum L.), an Israeli native, as a source of edible sprouts rich in antioxidants.
Vaknin Y, Hadas R, Schafferman D, Murkhovsky L, Bashan N.
Source–Department of Agronomy and Natural Resources, Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel. [email protected]
Abstract–The potential of wild plants in Israel as sources of edible sprouts has not been investigated until now. Milk thistle (Silybum marianum L.) is native to the Mediterranean basin and is now widespread throughout the world; its young fleshy stems are traditionally eaten by the local Arab sector in Israel, and its sprouts are rich in antioxidants and have been used as a traditional medicine for diseases of the liver and biliary tract. The active extract of milk thistle, silymarin, is a mixture of flavonolignans and is a strong antioxidant that has been proved to promote liver cell regeneration, to reduce blood cholesterol and to help prevent cancer. The present objective was to investigate the potential of milk thistle as a source of edible sprouts rich in antioxidants. We found that seed germination within 3-4 days was high (96%, except for striated seeds). Exposure to light significantly reduced sprout growth and significantly increased the polyphenol content and antioxidative capacity. The polyphenol content was 30% higher in seeds originating from purple inflorescences than in those from white ones. We thus found milk thistle to be a good candidate source of healthy edible sprouts.
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Milk thistle in liver diseases- past, present, future.
Abenavoli L, Capasso R, Milic N, Capasso F.
Source
Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy. [email protected]
Abstract
Silybum marianum or milk thistle (MT) is the most well-researched plant in the treatment of liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. Silybin is a component with the greatest degree of biological activity and makes up 50% to 70% of silymarin. Silymarin is found in the entire plant but it is concentrated in the fruit and seeds. Silymarin acts as an antioxidant by reducing free radical production and lipid peroxidation, has antifibrotic activity and may act as a toxin blockade agent by inhibiting binding of toxins to the hepatocyte cell membrane receptors. In animals, silymarin reduces liver injury caused by acetaminophen, carbon tetrachloride, radiation, iron overload, phenylhydrazine, alcohol, cold ischaemia and Amanita phalloides. Silymarin has been used to treat alcoholic liver disease, acute and chronic viral hepatitis and toxin-induced liver diseases.–PMID-20564545-[PubMed – indexed for MEDLINE]
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Recipe for Milk Thistle Usage—Take Milk thistle in seed form make a tea with it and take in conjunction with it 1000 mgs if Vitamin C and 1000mgs of MSM—this will increase the impact of the liver by increasing interferon production as welldetox the liver of harmful chemicals——If you are around solvents then you may want to add Arginine 500 mgs -1000mgs to the mix or even just add it to the milk thistle——If you have liver poisoning then add Alpha Lipoic Acid 100-200 mgs with vitamin C 1000mgs and milk thistle——For Excess Fat in the Liver you may want to increase B5 500-1000mgs and L Carnitine 500-2grams with it and the use of Taurine 500-1000mgs and Bile Salts (as suggested on the bottle)—–For issues in the restoring and regenerating of the liver —utilizing milk thistle with sage in equal parts in water and drinking—adding things like nettle and dandelion will assist as well in the blood purifying effect as well—-Sprouting the seeds –as well and consuming them will assist as well with the antioxidant effect of the herb and may even slow down the effects of aging
 
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Show of the Week March 30 2012
 
Metalloestrogens- A New Class Of Cancer-Causing Estrogens
 
What is Calorie Restriction (CR)?
 
Protocols for Reducing and Regenerating Colon health—Reduction in Body Mass
 
H. Pylori Bacteria Linked to Blood Sugar Control in Adult Type II Diabetes
 
The Truth About Cholesterol and Saturated Fat
 
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Metalloestrogens- A New Class Of Cancer-Causing Estrogens
Post date:
Sunday, March 18th 2012 at 10:00 am by Sayer Ji
this can be a male testis as well as a female breast having these metals in our endocrine system so the genders should be aware
Metals like aluminum have been linked to breast cancer for some time, but new research is confirming the existence of an entirely new class of cancer-causing estrogens known as “metalloestrogens,”[U1] and which are in thousands of consumer products — some which are even used in supplements and foods as “nutrients”…—-A new study published in journal Cancer Research reveals that dietary cadmium exposure increases the risk of postmenopausal breast cancer, confirming earlier research that a broad range of metals we are now being increasingly exposed to represent an emerging class of “metalloestrogens” with the potential to add to the estrogenic burden of the human breast. [U2]—In a 2006 report published in the Journal of Applied Toxicology, researchers found that the following metals were capable of binding to cellular estrogen receptors and then mimicking the actions of physiological estrogens: “aluminium, antimony, arsenite, barium, cadmium, chromium (Cr(II)), cobalt, copper, lead, mercury, nickel, selenite, tin and vanadate.” [U3]—-As we revealed in an earlier exposé on the use of toxic forms of selenium in USDA certified organic infant formula, exposure to sodium selenite (and sodium selenate) is difficult to avoid, as it is the primary source of supplemental selenium in mass market vitamins, foods, beverages, etc. The same is true for inorganic forms of chromium, copper, nickel, tin and and vanadium, which you will find on the labels of many mass market multivitamins. –Another daily source of metalloestrogen exposure for millions of consumers is aluminum-based antiperspirants. Investigations into the link between these personal care products and breast cancer risk came to a head earlier this year in a story we broke, and excerpt from below: –Aluminium salts used as antiperspirants have been incriminated as contributing to breast cancer incidence in Western societies. To date, very little or no epidemiological or experimental data confirm or infirm this hypothesis. We report here that in MCF-10A human mammary epithelial cells, a well-established normal human mammary epithelial cell model, long-term exposure to aluminium chloride (AlCl(3) ) concentrations of 10-300 µm, i.e. up to 100 000-fold lower than those found in antiperspirants, and in the range of those recently measured in the human breast, results in loss of contact inhibition and anchorage-independent growth.” [emphasis added]–If a metal can exhibit carcinogenic properties at a concentration 100,000-fold lower than presently used in personal care products, it is critical that there be a paradigm shift in the way toxicological risk assessments are performed. –Presently, the risk assessments depend on animal studies, where the goal is to find out how much of a chemical it takes to acutely kill 50% of an exposed population (LD50). Only then, is an “acceptable level of harm” extrapolated for humans (as if determining an “acceptable level of harm” were an ethically neutral objective). ——————–The problem is that humans are not mice, there are profound synergistic toxicities that are never accounted for when we are exposed to more than one chemical simultaneously,[U4] the LD50 does not indicate what constitutes a chronic/sublethal toxic dose or an acknowledgment that chronic toxic effects do occur at far lower doses, and mostly importantly for the purpose of this article, the concept of increasing toxicity as the concentration decreases is not even considered. —This, in fact, is what happens in certain types of radiation and petrochemical exposure. Low-dose radiation may be far more carcinogenic than high-dose radiation, which is why “early detection” through x-ray mammography is such a brutally dishonest practice, as it likely causes much more cancer than it is said to prevent. –This is also what happens with certain petrochemicals, e.g. bisphenol A, benzene, pthlatates, which is to say, they may be more toxic at lower concentration than higher ones, due to their hormone-mimicking, blocking and/or intensifying effects, as well as their ability to interact on a molecular level with cell surfaces and structures, which would not be possible were they aggregated in greater volumes or quantities. The entire field of nanotechnology, in fact, suffers from this counterintuitive problem: the smaller the size, the higher the potential toxicity or the greater the unintended, adverse health effects.——The problem of aluminum and similar metallogestrogen exposure, however, is greater than simply reforming manufacturers and consumer products. The military releases at least 500 tons of aluminum chaff annually during training within selected military operating areas in the United States, and only clandestine organizations know how much metal has been released into the environment in the name of “saving the earth” through “geoengineering.” Indeed, in what is known as Atmospheric Aerosol Spraying, our environment has increasingly become saturated through with metal pollution. The problem has become so bad that biotech corporations have begun engineering aluminum-resistant plants[U5], since many soils have become too acidified due to metal contamination to adequately sustain plants that produce food.
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What is Calorie Restriction (CR)?
The goal of Calorie Restriction is to achieve a longer and healthier life by
eating fewer calories
consuming adequate vitamins, minerals, and other essential nutrients
Extensive scientific research has shown that a CR diet improves the health and extends the lifespan of every species so far tested, including worms, spiders, rodents, dogs, cows and monkeys. We believe that people who adopt a CR diet will see the same results longer life and better health.
Getting Started
Simply eating less may not improve health or extend lifespan – it can lead to malnutrition.
Replace calorie-dense foods with calorie-sparse, nutrient-dense foods
Before worrying about how many calories you’re eating, make sure that the foods in your diet provide sufficient nutrition to avoid malnutrition once you begin to restrict them.
Avoid simple sugars and flours.
Sugars and flours generally contain very little nutrition for their calorie content. They also have high glycemic indices, which means that your body absorbs them quickly, leaving you wanting more a short time later.
Eat both green leafy (salad) and other vegetables.
Vegetables — both green leafy vegetables and non-leaf vegetables — contain the highest content of a wide variety of nutrients for their calorie content. By volume (and often by calories), vegetables are the major component of many calorie restricted but not nutrient deficient diets.
Carefully select your protein and fat sources.
Both protein and fat are required macronutrients, but their form can have a significant influence on a person’s risk factors for a wide variety of diseases.
Make sure your protein intake is sufficient, but not overly abundant.
Common recommendations for total protein intake range from 0.6 to 0.8 grams per kilogram of body weight, and some recommendations are much higher. This is probably a minimum.—another easier way to figure this out is to take either 60% of body weight or 80 % and multiply it by your weight this will give a close approximation of the amount of protein you should have—an example would be say a 110 lb person minimal amount would be 66grams a day and up to 88gams a day—take the .6 X 110=66— take .8 X110=88—or multiply the 60% X110 and remove the zero’s—again gives you 66 same with the 80% X 110 = 88—remove the zeros—will give a good approximation
Make sure your proteins are complete and balanced.
A complete protein contains all the essential amino acids, while a balanced protein contains all those amino acids in ratios that are most useful to human biophysiology.
Most animal proteins are complete and well-balanced
There are very few perfectly balanced proteins in our food supply, but animal proteins tend to be among the most balanced. Unfortunately, animal proteins also tend to include undesirable components. For example, red meat is carcinogenic [PMID: 12376502], and meat (especially red meat) and dairy often contain large quantities of saturated fats. The nutrient density (as always, on a per-calorie basis) of meats is often lower than other choices.—Again this is outdated badly—red meats should be broiled or cooked thoroughly after cleaned—but not to subsist on red meat totally which can be unhealthy—there are other animal proteins that are easier to consume and digest—this would be easier and more efficient for most
Non-animal proteins can be balanced by combining different food families
One can get extremely detailed in finding “complementary” foods, but in general, combining legumes (beans) or seeds or nuts in balance– will yield a balanced protein, and rice protein can complement the proteins in vegetables like broccoli, cauliflower, or spinach. Be aware, however, that both rice and grains (even whole grains) have relatively high glycemic indices and relatively low nutrient densities. If you’re going to consume these, choose Cassava or Some other form or Starch where potassium or other nutrients can be uptaken properly
Comment here this information is outdated badly due to the GMO and GE contamination You may want to reconsider these foods especially the rice an legumes which are high in starch ( sugars) and will turn to fat—-if consuming to act as a cleanse fashion then it would be best to utilize the fibres from other foods such as fruits and veges—most rice today is GMO’d and should be avoided
Select Healthy fats, and consume some Omega-3 fats
Foods containing monounsaturated fats include olive oil, almonds, hazelnuts, and avocados. Most of your fat intake should be from these foods. A very small amount of fat should be in the form of Omega-3 fatty acids, which are found in fatty fish (e.g. salmon) – ( minimize fish oils due to the mercury loads in these fish ) and flax oil, walnut oil, and perilla. Caution- fatty foods, even healthy choices, are high in calories so be sure that you carefully track your intake so as to stay within your Calorie goal.—
Get baseline blood tests done
In order to chart your progress, and to make sure that you are avoiding nutrient deficiencies and other hazards, get at least the minimal recommended blood tests done. You’ll want to know these results from before your calorie-restricted diet begins, so that you’ll have a baseline for comparison as you move into a calorie-restricted diet.
Reduce calories after improving diet quality (i.e. nutrition)
Once your diet consists primarily of nutrient-dense, calorie-sparse foods, you can safely begin to reduce your total calorie intake. There are some things to consider at this point, if you have not already considered them.
Lose weight slowly—-Many people lose weight simply by changing their diet to include more calorie-sparse foods. Even this weight loss should not be allowed to happen too quickly, but by the time you’re able to restrict calories, your weight loss should proceed very slowly. There are two reasons for this:
Pesticides and other toxins are fat soluble.
There are many pesticides and other toxins in our food supply that are fat soluble. Human bodies store these toxins relatively harmlessly in body fat. If you lose that fat too quickly, however, all these toxins are flushed into your bloodstream, and your detoxification mechanisms (i.e., your kidney and liver) are unable to remove them [B120YD, 78-80]. You may thus wind up with much higher blood toxin levels than what people are normally subjected to, which may have any number of life-shortening effects.
Sudden adult onset Calorie Restriction shortens the lifespans of mice.—Though the lifespan enhancing effects of calorie restriction have been known since the 1930s, it was also known that if adult mice were suddenly put on a calorie restricted diet, their lifespans were actually shortened. Dr. Walford found in the 1980s, however, that if mice were slowly transitioned from an ad lib to a calorie restricted diet, then their lifespans increased. The time for this transition recommended by Dr. Walford is a minimum of 6 to 9 months, but preferably 1 to 2 years. [p. 78, BY120YD]
Be aware of the potential risks in CR dieting!
Any significant dietary change should be done in consultation with a knowledgeable physician. There are several other risks that you should be aware of.
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Protocols for Reducing and Regenerating Colon health—Reduction in Body Mass
 
There are things needed to be applied In the area of reduction—and with reduction of body mass, there will be a reduction to the amount of poisons, toxins, build up and inflammation—So when applying these protocols do them at least once a month at any time of the month and watch unwanted health conditions disappear—and a new vigor come back.
 
Here is the NO list: NO : Bread(s) or any Facsimile of bread( crackers donuts, tacos, pita, breads ) – Pasta –Rice –Corn – Cereal ( not even oatmeal during this time ) Grains in general—No Stores bought Juices,-No Pop ( Soda for the easterners ) No Milk or Dairy Products that are Sugar or Fat Free—No Sugar (Brown or White or Pasteurized Honey- Agave Syrup ) Molasses-NO MICROWAVE ( not to be used any time—totally Damages the Body from cellular level to tissues and DNA damaging ) Margarine-Canola Oil – Vegetable Oil – Soybean oil ( or any Soy whatsoever or any Derivatives – TVP –HVP – AVP –HPP – MSG –Disodium Guanylate – Disodium Inosinate-Bananas – Grapes – Raisons – Watermelon—Dates-Pork or Pork Byproducts ( sausauges, bacon, hot dogs, pork rinds etc)
 
Here is the YES List: Yes to -Meat – Poultry –Fish –Lamb – Eggs – Yogurt ( Plain and with Fat ) Kefir ( plain and with Fat ) Whey Protein – Gelatin Broths ( Plain or Vanilla Without Artificial Sweetners –Aspartame—Splenda – Aceslfame Potassium ) Cottage Cheese ( unless you have a yeast or fungal infection ) Cream – Olive oil – Butter – Ghee – Almond Oil – Pumpkin Seed Oil – Macadamian Nut Oil – Apricot oil – Sesame Seed Oil – Coconut Oil- Palm Oil – Animal Fat ( try to make sure the animals are GRASS FED not GRAIN FED—the fat then will be beneficial if the fat is from a grass Fed Animal ) Fruit with Fibre ( Apple, Peaches, Plums, Pears, Apricot, Nectarines etc PEEL BEFORE CONSUMING TO MINIMIZE PESTICIDE OR WAXES even if organic)Citrus Fruits – Oranges – Lemons – Pommelo’s – Grapefruit – Tangerines- Mannelos, etc Berries ( Wash and clean with either Peroxide. GSE, Vinegar, Lemon Juice- Use an Iodine Spray ) Veggies all kinds (Wash and clean with either Peroxide. GSE, Vinegar, Lemon Juice- Use an Iodine Spray ) Make Juice fresh and Home made Use Sprouts—Seeds – Nuts – Make Nut or Seed butters—
Do this for 5-10 days and afterwards if you wish to consume rice or pasta or polenta then introduce them back slow and minimize the consumption—breads if you consume then utilize Rye, Barley, or Oat and again Minimally—the idea is to get off breads and cereals which are actually Fermenting inside and potentially causing DNA damage and Restructuring— Potato Can be used as long as it is not fried—Can be used if -broiled—boiled—mashed-or baked this will assist in the cleansing of the colon as well as provide energy
 
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H. Pylori Bacteria Linked to Blood Sugar Control in Adult Type II Diabetes
 
A new study by researchers at NYU Langone Medical Center reveals that the presence of Helicobacter pylori (H. pylori) bacteria is associated with elevated levels of glycosylated hemoglobin (HbA1c), an important biomarker for blood glucose levels and diabetes.)—ScienceDaily (Mar. 14, 2012) — A new study by researchers at NYU Langone Medical Center reveals that the presence of Helicobacter pylori (H. pylori) bacteria is associated with elevated levels of glycosylated hemoglobin (HbA1c), an important biomarker for blood glucose levels and diabetes. The association was even stronger in obese individuals with a higher Body Mass Index (BMI).—The results, which suggest the bacteria may play a role in the development of diabetes in adults, are available online in The Journal of Infectious Diseases.—There have been several studies evaluating the effect of the presence of H. pylori on diabetes outcomes, but this is the first to examine the effect on HbA1c, an important, objective biomarker for long-term blood sugar levels, explained Yu Chen, PhD, MPH, associate professor of epidemiology at NYU School of Medicine, part of NYU Langone Medical Center. “The prevalence of obesity and diabetes is growing at a rapid rate, so the more we know about what factors impact these conditions, the better chance we have for doing something about it,” Dr. Chen said. Looking at the effects of H. pylori on HbA1c, and whether the association differs according to BMI status, provided what could be a key piece of information for future treatment of diabetes, she explained.—Type II diabetes causes an estimated 3.8 million adult deaths globally. There have been conflicting reports about the association between H. pylori infection and type II diabetes. To better understand the relationship between H. pylori and the disease, Dr. Chen and Martin J. Blaser, MD, the Frederick H. King Professor of Internal Medicine and professor of microbiology, analyzed data from participants in two National Health and Nutrition Surveys (NHANES III and NHANES 1999-2000) to assess the association between H. pylori and levels of HbA1c.—-“Obesity is an established risk factor for diabetes and it is known that high BMI is associated with elevated HbA1c. Separately, the presence of H. pylori is also associated with elevated HbA1c,” said Dr. Blaser, who has studied the bacteria for more than 20 years. “We hypothesized that having both high BMI and the presence of H. pylori would have a synergistic effect, increasing HbA1c even more than the sum of the individual effect of either risk factor alone. We now know that this is true.”—-H. pylori lives in the mucous layer lining the stomach where it persists for decades. It is acquired usually before the age of 10, and is transmitted mainly in families. Dr. Blaser’s previous studies have confirmed the bacterium’s link to stomach cancer and elucidated genes associated with its virulence, particularly a gene called cagA.
Regarding H. pylori’s association with elevated HbA1c, Drs. Chen and Blaser believe the bacterium may affect the levels of two stomach hormones that help regulate blood glucose, and they suggest that eradicating H. pylori using antibiotics in some older obese individuals could be beneficial.—More research will be needed to evaluate the health effects of H. pylori and its eradication among different age groups and in relation to obesity status, the authors noted.”If future studies confirm our finding, it may be beneficial for individuals at risk for diabetes to be tested for the presence of H. pylori and, depending on the individual’s risk factor profile” Dr. Chen.—–In an accompanying editorial in The Journal of Infectious Diseases, Dani Cohen, PhD, of Tel Aviv University in Israel, pointed out that while previous studies have addressed the association between type II diabetes and H. pylori in small samples, this study analyzed two independent large national samples of the general population. Dr. Cohen agreed with the study authors, suggesting that adults infected with H. pylori with higher BMI levels, even if asymptomatic, may need anti-H. pylori therapy to control or prevent type II diabetes. If the study findings are confirmed, Dr. Cohen wrote, they “could have important clinical and public health implications.”–Story Source-The above story is reprinted from materials provided by NYU Langone Medical Center, via Newswise.
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The Truth About Cholesterol and Saturated Fat
 
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[U1]Chemtrail fallout has Over 28 components and one of them is aluminum not to mention managese and barium and uranium and thorium
[U2]Not Just the breast—the whole endocrine system
[U3]Some of these are in the chemtrails
[U4]Again—take the 28 components of chemtrails—add that to the water you drink if you are still drinking from the tap—then figire out the levels in your plants ( organic or otherwise since they will uptake the toxic metals as well from the ground released by the pesticides and chemtrails) and you now have a chemical mix killing or debilitating a human being
[U5]Which will further increase the levels in our system since these plants will be able to absorb more of the metal —it makes them more resistant –not more healthy—big difference