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Transcranial magnetic stimulation holds promise for tinnitus patients In the largest U.S. clinical trial of its kind funded by the Veterans Affairs (VA) Rehabilitation Research and Development Service, researchers at the VA Portland Medical Center and Oregon Health & Science University found that transcranial magnetic stimulation significantly improved tinnitus symptoms for more than half of study participants. Their findings were published today in the journal JAMA Otolaryngology - Head & Neck Surgery.--"For some study participants, this was the first time in years that they experienced any relief in symptoms. These promising results bring us closer to developing a long-sought treatment for this condition that affects an enormous number of Americans, including many men and women who have served in our armed forces," said Robert L. Folmer, Ph.D., research investigator with the National Center for Rehabilitative Auditory Research at the VA Portland Health Care System and associate professor of Otolarynology/Head and Neck Surgery in the OHSU School of Medicine.--One of the most common health conditions in the country, tinnitus affects nearly 45 million Americans. People with this audiological and neurological condition hear a persistent sound - that can range from ringing or buzzing to a hissing or white noise hum - when there is no external sound source. The distraction can impair people's ability to sleep or concentrate and is sometimes disabling.--[F1]According to the Centers for Disease Control and Prevention, nearly 15 percent of Americans experience some degree of tinnitus. Currently, there are no proven treatments available. So, patients with the condition often develop coping strategies to manage their reaction to tinnitus.--Military veterans are at greater risk of developing the condition. Tinnitus is the most prevalent service connected disability in the VA health system. Study participants were a mix of veterans and non-veterans.--"We applaud the work of Dr. Folmer and his colleagues. The results of the joint National Center for Rehabilitative Auditory Research/OHSU study are promising for tinnitus patients everywhere," said Melanie West, Chair of the American Tinnitus Association's Board of Directors, the premier member-based tinnitus organization. "We are committed to finding solutions for tinnitus and excited to see the progression of TMS clinical trials producing positive results for some patients."--To conduct this research, Folmer and colleagues, including Sarah Theodoroff, Ph.D., used a TMS system that generates a cone-shaped magnetic field that penetrates the scalp and skull to interact with brain tissue. The higher the stimulation intensity, the deeper the magnetic field can penetrate and affect neural activity. Currently, the Food and Drug Administration has approved transcranial magnetic stimulation only for treatment of depression. All 64 participants enrolled in the study received one pulse of TMS per second to their skull just above the ear to target the auditory cortex in the brain[F2]. Participants underwent TMS sessions on 10 consecutive workdays, receiving 2,000 pulses of TMS per session. Of the 32 participants who received the "active" TMS treatment, 18 people found their symptoms were alleviated for at least six months. To participate in the study, patients were required to have had tinnitus for at least a year or more.--A significant number of participants who had tinnitus for more than 20 years were pleased to receive some relief from TMS treatment. In light of these encouraging results, Dr. Folmer hopes to conduct a larger clinical trial to refine protocols for the eventual clinical use of TMS for tinnitus.---Source-Oregon Health & Science University Recipe With Magnets—make a band of a magnetic strip—and apply round earth magnets to the strip so they are one on one side and one on the other- and then apply some tape – chose what ever you wish) and then place either above on the head or allot it to be a choker type under the ear on the neck ---if applied before bed and you have some kind of shielding you may find it is unusually quiet-due to the magnetic field you have placed on the head or neck *************************************************************************** Curcumin and chronic kidney disease (CKD): major mode of action through stimulating endogenous intestinal alkaline phosphatase. Molecules. 2014;19(12):20139-56 Authors: Ghosh SS, Gehr TW, Ghosh S Abstract Curcumin, an active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa),[F3] has significant anti-inflammatory properties. Chronic kidney disease (CKD), an inflammatory disease, can lead to end stage renal disease resulting in dialysis and transplant. Furthermore, it is frequently associated with other inflammatory disease such as diabetes and cardiovascular disorders. This review will focus on the clinically relevant inflammatory molecules that play a role in CKD and associated diseases. Various enzymes, transcription factors, growth factors modulate production and action of inflammatory molecules; curcumin can blunt the generation and action of these inflammatory molecules and ameliorate CKD as well as associated inflammatory disorders. Recent studies have shown that increased intestinal permeability results in the leakage of pro-inflammatory molecules (cytokines and lipopolysaccharides) from gut into the circulation in diseases such as CKD, diabetes and atherosclerosis. This change in intestinal permeability is due to decreased expression of tight junction proteins and intestinal alkaline phosphatase (IAP). Curcumin increases the expression of IAP and tight junction proteins and corrects gut permeability. This action reduces the levels of circulatory inflammatory biomolecules. This effect of curcumin on intestine can explain why, despite poor bioavailability, curcumin has potential anti-inflammatory effects in vivo and beneficial effects on CKD. --PMID: 25474287 [PubMed - indexed for MEDLINE] *******************************************************************8 Cell division speeds up as part of antibody selection Rockefeller University. "Cell division speeds up as part of antibody selection: Research reveals new details about the process by which the immune system refines its antibodies." ScienceDaily. ScienceDaily, 16 July 2015. <www.sciencedaily.com/releases/2015/07/150716160559.htm>. It's a basic principle of immunology: When a germ invades, the body adapts to that particular target and destroys it. But much remains unknown about how the immune system refines its defensive proteins, called antibodies, to most effectively zero in on that invader. Experiments at The Rockefeller University offer new insight into the details of this selection process.--In research published in Science on July 16, scientists led by Michel Nussenzweig, Zanvil A. Cohn and Ralph M. Steinman Professor and head of the Laboratory of Molecular Immunology, uncovered a new mechanism by which the B cells that produce the most finely tuned antibodies rise to dominance. This discovery builds on earlier work published last year.--"Through a process called affinity maturation B cells compete, and those cells that produce the highest affinity antibodies win and come to dominate the B cell population. Our work so far has revealed two of the mechanisms that allow high affinity B cells to overwhelm the others," says Alex Gitlin, a graduate student in the lab and first author of the paper.--B cells have genes that code for antibodies, which latch onto foreign proteins, called antigens, as part of an immune response. During an infection, B cells and other immune cells form tiny structures called germinal centers in the spleen and lymph nodes[F4].--Within germinal centers, B cells evolve in a Darwinian-like fashion. The gene responsible for producing their antibodies mutates rapidly, a million times faster than the normal rate of mutation in the human body, and the cells proliferate. B cells whose mutations increase the antibody's affinity for the antigen are selected, and these cells then continue to mutate and proliferate.--"Previously, we showed that high affinity cells spend more time dividing and mutating in between rounds of competition. We now show that these high affinity cells also use this additional time more effectively -- by dividing at faster rates," Gitlin says. In this manner, the germinal center produces the high affinity antibodies that are the basis of an effective immune response.--Vaccines[F5] initiate this process by exposing the body to pieces of a pathogen or to a weakened or dead version of it, prompting the immune system to develop protective antibodies. Because vaccines depend on effective antibody responses for protection, a better understanding of the antibody selection process in the germinal center might potentially be of use for developing more effective vaccines.--The team's research has focused on the dynamics inside the germinal center. Within it, B cells travel between two areas known as the dark zone and the light zone. In the dark zone, the B cells mutate and proliferate, before traveling to the light zone, where they pick up pieces of antigen. The higher the affinity of their antibodies, the more antigen they pick up. Their previous experiments demonstrated that another type of immune cell, the T cell, operates in the light zone to recognize the higher affinity B cells based on the amount of antigen they display. The more antigen the B cells present to T cells, the stronger the signal the T cells send. As a result, the high affinity B cells spend more time in the dark zone in between visits to the light zone.--This time, the team, which also included collaborators at Memorial Sloan Kettering Cancer Center and Harvard Medical School, identified another reason the high affinity cells come to dominate: more rapid cell divisions. They induced the selection of an engineered set of B cells in mice, and used labels that the cells incorporate as they replicate their DNA in preparation for cell division. With these techniques they found that a signal from the T cell also prompts the high affinity B cells to divide more rapidly while in the dark zone. In effect, these cells have both more time and more speed with which to duplicate themselves[F6].--By labeling DNA replication and following its progression, the team took a close look at how the S phase of the cell cycle, in which the cell copies its DNA in preparation for division,[F7] is sped up. They found that acceleration during this phase was due to the double-stranded DNA molecule being unzipped and copied more rapidly at the so-called replication fork.--"Together, these studies describe two complementary ways in which signals from T cells empower the best equipped set of B cells to take over the immune response during affinity maturation. Other mechanisms, which are yet to be discovered, are also likely to be at play," Gitlin says. "The dynamics of germinal centers are crucial to this basic immunological process, and they may also have important implications for improving vaccines and understanding lymphomas, which often arise from germinal center B cells due to their high rates of proliferation and mutation."-Story Source--The above post is reprinted from materials provided by Rockefeller University. Note: Journal Reference-Alexander D. Gitlin, Christian T. Mayer, Thiago Y. Oliveira, Ziv Shulman, Mathew J. K. Jones, Amnon Koren, Michel C. Nussenzweig. T cell help controls the speed of the cell cycle in germinal center B cells. Science, 2015 DOI: 10.1126/science.aac4919 ************************************************************************* C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1). Bratisl Lek Listy. 2015;116(2):132-5 Authors: Assadollahi V, Gholami M, Zendedel A Abstract OBJECTIVE: The aim of this study was to evaluate the effect of C. zeylanicum aqueous extract on cell growth in the human myelocytic leukemia cell line (THP-1). BACKGROUND: Today, application of Cinnamon for treatment of cancer investigates extensively. Cinnamon has antioxidant, anti-apoptotic and anti-inflammatory properties. METHODS: In this experimental study, THP-1 was incubated in 2, 1, 0.1 and 0.01 mg/ml C. zeylanicum solutions for 24, 48 and 72 hours. Cell cycle was assessed with flow cytometry. Apoptotic cells were identified by Hoechst 33342 staining. Cell proliferation was assessed by the MTT assay. The data were analyzed using descriptive statistics and analytical tests. RESULTS: Samples that supplemented with 0.1 mg/ml C. zeylanicum aqueous extract enhanced induction of apoptosis in THP-1 cell line compared to samples that supplemented with 2, 1 and 0.01 mg/ml. According to flow cytometry analysis, after 24 and 72 hours of incubation in 0.1 and 2 mg/ml C. zeylanicum aqueous extract, respectively, the amount of cells in apoptosis phase was higher than that in the control sample. CONCLUSION: Supplemented C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (Fig. 4, Ref. 20).-PMID: 25665482 [PubMed - indexed for MEDLINE] ***********************************************************************8 Behavioral Structural Functional Abnormalities associated with various Heavy Metal Toxins   Behavioral Structural Functional Abnormalities associated with various Heavy Metal Toxins Psychiatric Disturbances Social Deficits, Social withdrawal Mercury Repetitive perseverative stereotyped behaviors, OCD-typical behaviors Mercury Depression mood swings flat affect impaired facial recognition Arsenic, Copper, Lead, Mercury Schizoid tendencies, hallucinations, delirium Mercury Irritability aggressive behaviors temper tantrums Lead, Mercury Suicidal Behaviors Copper, Mercury Sleep difficulties/ disturbances Lead, Mercury, Thallium Chronic fatigue (CFS), weakness, malaise Aluminum, Arsenic, Cadmium, Copper, Lead, Mercury, Thallium Anorexia, symptoms reflecting eating disorders loss of appetite/weight Arsenic, Lead, Mercury Anxiety, nervous tendencies Thallium Attention problems (ADHD) lacks eye contact impaired visual fixation Lead, Mercury Speech and Language Deficits Speech disorders Aluminum, Mercury Loss of speech developmental problems with language Mercury Speech comprehension deficits Mercury Dysarthria, articulation problems slurred speech, unintelligible speech Mercury Cognitive Impairments Mental retardation borderline intelligence Arsenic, Lead, Mercury Uneven performance on IQ scores low IQ scores Copper, Lead Poor concentration attention deficits (ADHD) response inhibition Aluminum, Lead Poor memory (short term verbal and auditory) Aluminum, Lead Dementia pre-senile and senile dementia Aluminum Stupor Aluminum, Arsenic Impaired reaction time lower performance on timed tests Lead Sensory Abnormalities Abnormal Sensations in the mouth and extremities Arsenic Hearing loss difficulty hearing Arsenic, Lead, Mercury Abnormal touch sensations, diminished touch sensations aversion to touch Arsenic Blurred vision, sensitivity to light Arsenic, Mercury Motor Disorders Choreiform movements myoclonal jerks unusual postures Copper, Mercury Difficulty walking swallowing talking Copper, Mercury Flapping circling rocking toe walking Mercury Problems with intentional movements or imitation Mercury Abnormal gait/posture, uncoordination loss of balance, problems sitting lying crawling and walking Mercury Decreased locomotor activity Aluminum, Arsenic Convulsions, seizure Aluminum, Arsenic, Copper, Lead, Mercury, Thallium   Structural and Functional Abnormalities associated with various heavy metal toxins Physiological Impairment Brain and Central Nervous System Neurofibrillary tangles Aluminum Neuritis retrobulbar neuritis neuropathy Aluminum, Arsenic, Thallium Encephalopathy Aluminum, Arsenic, Lead, Thallium Alterations in nerve conduction velocity Lead Alterations in the spinal chord Thallium Accumulates in CNS structures Aluminum, Mercury Abnormal EEGs Arsenic, Lead Autonomic disturbances Copper, Lead, Mercury, Thallium Peripheral Nervous System Peripheral neuropathy Arsenic, Mercury Alterations in peripheral nerves Arsenic Loss of feeling/ numbness in the extremities, parasthesia Arsenic, Mercury, Thallium Gastrointestinal Tract Nausea vomiting diarrhea loss of appetite Arsenic, Copper, Mercury, Thallium Abdominal pain stomach cramps burning of the throat and mouth Arsenic, Copper, Lead, Mercury, Thallium Esophagitis, gastroenteritis, colitis Arsenic, Mercury, Thallium Cancers (colon pancreatic stomach or rectal) Arsenic Renal and Hepatic Impairment Hepatotoxicity Liver dysfunction damage Arsenic, Copper, Thallium Cirrhosis of the liver, hepatitis Copper Kidney disease, kidney failure Arsenic, Lead, Mercury Renal toxicity, tubular proteinosis Arsenic, Copper, Lead Kidney Damage histological alterations Arsenic, Lead Cardiovascular System Blood vessel damage Arsenic Anemia, decreased red blood cell count Arsenic, Copper, Lead Hypertension, increased heart rate (tachycardia) Arsenic, Copper, Lead, Thallium Electrocardiac disorders Peripheral vascular disease, cardiovascular disease, vascular collapse Arsenic, Lead Respiratory System Pulmonary Fibrosis Aluminum, Arsenic Pneumonia laryngitis pharyngitis bronchitis Aluminum, Arsenic, Mercury Restrictive airway disorders asthmatic conditions pneumoconisis Arsenic, Aluminum Respiratory tract cancers Arsenic Immune System Immunosuppression Lead Decreased white blood cell count Arsenic, Thallium Reproductive System Genital abnormalities Aluminum, Thallium Disturbances in menstrual cycle menstrual pains Copper, Mercury Birth defects, premature births, spontaneous abortion Arsenic, Lead, Mercury Reproductive dysfunction Arsenic, Aluminum, Cadmium, Lead Other Physical Disturbances Rashes contact dermatitis eczema itchy/irritating skin Aluminum, Arsenic, Copper, Mercury Muscle pain, headache, acrodynia, colic Arsenic, Copper, Lead, Thallium Alopecia (hair loss) Thallium     ***************************************************************************** 3D printers poised to have major implications for food manufacturing Date-July 13, 2015 Source-Institute of Food Technologists (IFT)   Summary-The use of 3D printers has the potential to revolutionize the way food is manufactured within the next 10 to 20 years, impacting everything from how military personnel get food on the battlefield to how long it takes to get a meal from the computer to your table, according to new research.   The use of 3D printers has the potential to revolutionize the way food is manufactured within the next 10 to 20 years, impacting everything from how military personnel get food on the battlefield to how long it takes to get a meal from the computer to your table, according to a July 12th symposium at IFT15: Where Science Feeds Innovation hosted by the Institute of Food Technologists (IFT) in Chicago.--The price of 3D printers has been steadily declining, from more than $500,000 in the 1980s to less than $1,000 today for a personal-sized device, making them increasingly available to consumers and manufacturers Although they are not widely used in food manufacturing yet, that availability is fueling research into how they can be used to customize foods or speed delivery of food to consumers."No matter what field you are in, this technology will worm its way in," said Hod Lipson, Ph.D., a professor of engineering at Columbia University and a co-author of the book Fabricated: The New World of 3D Printing. "The technology is getting faster, cheaper and better by the minute. Food printing could be the killer app for 3D printing."-Lipson, addressing the conference by video, said 3D printing is a good fit for the food industry because it allows manufacturers to bring complexity and variety to consumers at a low cost. Traditional manufacturing is built on mass production of the same item, but with a 3D printer, it takes as much time and money to produce a complex, customized product that appeals to one person as it does to make a simple, routine product that would be appealing to a large group.-For example, Lipson said, users could choose from a large online database of recipes, put a cartridge with the ingredients into their 3D printer at home, and it would create the dish just for that person. The user could customize it to include extra nutrients or replace one ingredient with another. The U.S. military is just beginning to research similar uses for 3D food printing, but it would be used on the battlefield instead of in the kitchen, said Mary Scerra, food technologist at the U.S. Army Natick Soldier Research, Development and Engineering Center (NSRDEC) in Natick, Massachusetts. She said that by 2025 or 2030, the military envisions using 3D printing to customize meals for soldiers that taste good, are nutrient-dense, and could be tailored to a soldier's particular needs. "Imagine warfighters in remote areas -- one has muscle fatigue, one has been awake for a long period without rest, one lacks calories, one needs electrolytes, and one just wants a pizza," Scerra said. "Wouldn't it be interesting if they could just print and eat?"--She noted that there are still several hurdles to overcome, such as the cost of bringing the technology to remote areas, the logistics of making it work in those locations and, perhaps most importantly, making sure the food tastes good.-"If the meals aren't palatable, they won't be consumed," Scerra said. "It doesn't matter how nutritious they are."-Anshul Dubey, research and development senior manager at PepsiCo, said 3D printing already is having an impact within the company, even though it is not yet being used to make food. For example, consumer focus groups were shown 3D-printed plastic prototypes of different shaped and colored potato chips. He said using a prototype such as that, instead of just a picture, elicits a more accurate response from the focus group participants.--"Even though the future of food 3D printing looks far off, that doesn't mean it's not impacting the industry," he said.Story Source--The above post is reprinted from materials provided by Institute of Food Technologists (IFT). Institute of Food Technologists (IFT). "3D printers poised to have major implications for food manufacturing." ScienceDaily. ScienceDaily, 13 July 2015. <www.sciencedaily.com/releases/2015/07/150713144118.htm   TOP A [F1]Key word here is no external sound –then this must be a frequency and as a result of the magnetic field surrounding the head it would block the frequency which maybe transmitting from the inside out or a receptor may be entering in as a result the filed acts as a wall and blocks the transmission from entering [F2]This is where you may want to apply an experiment using either a electromagnet or a earth neodyme magnet [F3]Tumeric Herb ( spice) [F4]It would appear to sustain the impact of the immune system then the lymph and spleen to be upheld and maintained [F5]Have never worked or have ever been proven to work and now with the nano delivery system and and the XNA incorporated in the delivery this is not the same and can even bypass the immune system –instead of triggering a immune response will cause a dysfunction [F6]This as well could be where nano particle cluster to wait for an opportunity to sabotage the replication [F7]What if there was another XNA in there –would it be able to overwrite what can happen when this is being added